Latanoprost nonresponders with open-angle glaucoma in the Japanese population
Latanoprost nonresponders with open-angle glaucoma in the Japanese population
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DOI：
10.1007/s10384-005-0293-x
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发表时间：
2006-03-01
影响因子：
2.4
通讯作者：
Kinoshita, S
中科院分区：
文献类型：
--
作者：
Ikeda, Y;Mori, K;Kinoshita, S
目的：由于部分患者对拉坦前列素疗效不佳。作为最有效的外用青光眼药物之一，我们调查了拉坦前列素无反应者(LNR)在日本人群中的发生率和临床特征。方法：我们检查了62例(62只眼)仅使用拉坦前列素3个月以上的青光眼患者。平均年龄63.8±1.8岁，平均观察期9.7±0.4个月。在1、3、6和12个月时测量眼压(TOP)。计算最大下降率(RR)和最低下降率(RR值均小于或等于10%)。结果：1、3、6、12个月的RR分别为20.1+/-2.0%、118.8+/-2.3%、+/-21.1+/-2.8%。23.0+/-2.6%。分别进行了分析。同一时间点，LNR发生率分别为23.1%、28.1%、23.5%和31.8%。分别进行了分析。基线最高血压值低于15毫米汞柱的患者显著升高。结论：包括正常眼压性青光眼(NTG)患者在内的日本人群中LNR的发病率高于欧美患者。仅低基线TOP是LNR的一个重要临床因素。
Purpose: As some patients show little response to latanoprost. one of the most powerful topical glaucoma medications, we investigated the incidence and clinical profiles of latanoprost nonresponders (LNR) in the Japanese population.Methods: We examined 62 glaucoma patients (62 eyes) who had received only latanoprost for more than 3 months. Their mean age was 63.8 +/- 1.8 years; the mean observation period was 9.7 +/- 0.4 months. At 1. 3, 6, and 12 months, their intraocular pressure (TOP) was measured. and the TOP reduction rate (RR) and the rate of LNR, defined as RR of 10% or less, were calculated. We statistically analyzed clinical factors involved in the LNR status of our study population.Results: At 1,3,6, and 12 months, RR was 20.1 +/- 2.0%, 118.8 +/- 2.3% +/- 21.1 +/- 2.8%. and 23.0 +/- 2.6%. respectively. At the same time points, the LNR incidence was 23.1 %, 28.1 %, 23.5%, and 31.8%. respectively. and significantly higher in patients whose baseline TOP was less than 15 mmHg. Patient sex and age and the glaucoma type played no significant role in the LNR status.Conclusions: The incidence of LNR in the Japanese population, including normal-tension glaucoma (NTG) patients, is higher than among European or American patients. Only low baseline TOP was a significant clinical factor among LNR.