A putative greigite-type magnetosome gene cluster from the candidate phylum Latescibacteria
A putative greigite-type magnetosome gene cluster from the candidate phylum Latescibacteria
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来自候选 Latescibacteria 门的推定灰石型磁小体基因簇。
DOI：
10.1111/1758-2229.12234
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发表时间：
2015-04-01
影响因子：
3.3
通讯作者：
Pan, Yongxin
中科院分区：
文献类型：
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作者：
Lin, Wei;Pan, Yongxin
趋磁细菌（MTB）中磁铁矿和/或灰岩磁小体的细胞内生物矿化受到一组保守基因（称为磁小体基因）的严格控制，这些基因在MTB基因组中组织为簇（或岛）。到目前为止，所有报道的 MTB 都属于变形菌门、硝化螺旋门和候选菌门 OP3。在这里，我们报告了 Rinke 及其同事最近从属于候选 Latescibacteria（以前的候选部门 WS3）的未培养细菌的基因组草案中发现了推定的磁小体基因簇结构，其中包含 10 个与趋磁变形菌门和 Nitrospirae 的磁小体妈妈基因同源的基因。此外，这些基因在系统发育上与之前仅在Deltaproteobacteria MTB中发现的greigite型磁小体基因密切相关，这表明greigite基因的起源可能比之前想象的更早。这些发现表明，乳杆菌门的一些成员可能能够形成灰石磁小体，因此可能在环境铁和硫循环中发挥以前未被认识到的作用。 Latescibacteria门磁小体基因簇的保守基因组结构支持了这些基因在自然界中远缘相关细菌群之间水平转移的假设。
The intracellular biomineralization of magnetite and/or greigite magnetosomes in magnetotactic bacteria (MTB) is strictly controlled by a group of conserved genes, termed magnetosome genes, which are organized as clusters (or islands) in MTB genomes. So far, all reported MTB are affiliated within the Proteobacteria phylum, the Nitrospirae phylum and the candidate division OP3. Here, we report the discovery of a putative magnetosome gene cluster structure from the draft genome of an uncultivated bacterium belonging to the candidate phylum Latescibacteria (formerly candidate division WS3) recently recovered by Rinke and colleagues, which contains 10 genes with homology to magnetosome mam genes of magnetotactic Proteobacteria and Nitrospirae. Moreover, these genes are phylogenetically closely related to greigite-type magnetosome genes that were only found from the Deltaproteobacteria MTB before, suggesting that the greigite genes may originate earlier than previously imagined. These findings indicate that some members of Latescibacteria may be capable of forming greigite magnetosomes, and thus may play previously unrecognized roles in environmental iron and sulfur cycles. The conserved genomic structure of magnetosome gene cluster in Latescibacteria phylum supports the hypothesis of horizontal transfer of these genes among distantly related bacterial groups in nature.