Estrogen Receptor and Signal Transducer and Activator of Transcription 3 Expression in Equine Mammary Tumors
Estrogen Receptor and Signal Transducer and Activator of Transcription 3 Expression in Equine Mammary Tumors
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DOI：
10.1177/0300985814559400
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发表时间：
2015-07-01
影响因子：
2.4
通讯作者：
Foote, A. K.
中科院分区：
文献类型：
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作者：
Hughes, K.;Scase, T. J.;Foote, A. K.
马乳腺肿瘤是罕见的，相对稀疏的组织病理学和分子数据存在。本研究描述了7个这样的肿瘤的组织病理学特征，表现为浸润性生长，中等到高的有丝分裂率，局灶性广泛坏死。肿瘤表现为波形蛋白和细胞角蛋白14的强染色，以及泛细胞角蛋白的弱染色。E-cadherin表达强。有趣的是，一个亚组的肿瘤表现出强烈的雌激素受体核染色。7例肿瘤中有3例显示转录因子STAT 3的核表达，表明STAT 3具有转录活性。在细胞角蛋白14中度至强烈染色的癌中观察到罕见至缺失的细胞核STAT 3表达。本研究证实了先前研究者的断言，即马乳腺肿瘤具有恶性表型。马乳腺肿瘤的一个子集表现出雌激素受体的表达，这表明这些肿瘤可能具有类似的分子特征，他们的猫和犬的同行。
Equine mammary tumors are uncommon, and relatively sparse histopathologic and molecular data exist. The present study describes the histopathologic features of 7 such tumors, which exhibited infiltrative growth, intermediate to high mitotic rates, and focally extensive necrosis. The tumors exhibited variably strong staining for vimentin and cytokeratin 14, as well as frequently weak cytoplasmic staining for pan-cytokeratin. E-cadherin expression was strong. Interestingly, a subgroup of the tumors exhibited strong nuclear staining for estrogen receptor . Three of 7 tumors exhibited nuclear expression of the transcription factor STAT3, suggesting that STAT3 was transcriptionally active. Rare to absent nuclear STAT3 expression was observed in carcinomas exhibiting moderate to intense staining for cytokeratin 14. This investigation confirms previous investigators' assertions that equine mammary tumors have a malignant phenotype. A subset of the equine mammary tumors exhibited estrogen receptor expression, suggesting that these tumors may potentially have similar molecular characteristics to their feline and canine counterparts.