Toward a model for Arf GTPases as regulators of traffic at the Golgi.
Toward a model for Arf GTPases as regulators of traffic at the Golgi.
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DOI:
10.1016/j.febslet.2009.10.066
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发表时间:
2009-12-03
期刊:
影响因子:
3.5
通讯作者:
Kahn, Richard A.
中科院分区:
文献类型:
--
作者:
Kahn, Richard A.
关键词:
In this review I summarize the likely roles played by Arf proteins in the regulation of membrane traffic at the Golgi, from the perspective of the GTPase. The most glaring limitations to the development of a coherent molecular model are highlighted; including incomplete information on the initiation of Arf activation, identification of the “accessory proteins” required for carrier maturation and scission, and those required for directed traffic and fusion at the destination membrane. Though incomplete, the molecular model of carrier biogenesis has developed rapidly in recent years and promises richness in understanding this essential process.
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