Toward a model for Arf GTPases as regulators of traffic at the Golgi.

Toward a model for Arf GTPases as regulators of traffic at the Golgi.
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DOI:
10.1016/j.febslet.2009.10.066
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发表时间:
2009-12-03
期刊:
影响因子:
3.5
通讯作者:
Kahn, Richard A.
Kahn, Richard A.
中科院分区:
生物学3区
文献类型:
--
作者:
Kahn, Richard A.

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在这篇综述中,我总结了可能的作用,Arf蛋白在高尔基体的膜交通的调节,从GTdR的角度来看。一个连贯的分子模型的发展的最明显的局限性突出,包括不完整的信息启动Arf激活,识别载体成熟和断裂所需的“辅助蛋白”,以及那些需要定向交通和融合在目的地膜。虽然不完整,载体生物合成的分子模型近年来发展迅速,并承诺丰富了解这一重要过程。
In this review I summarize the likely roles played by Arf proteins in the regulation of membrane traffic at the Golgi, from the perspective of the GTPase. The most glaring limitations to the development of a coherent molecular model are highlighted; including incomplete information on the initiation of Arf activation, identification of the “accessory proteins” required for carrier maturation and scission, and those required for directed traffic and fusion at the destination membrane. Though incomplete, the molecular model of carrier biogenesis has developed rapidly in recent years and promises richness in understanding this essential process.
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