The safety and efficacy of Australian tickborne disease vaccine strains in cattle in Paraguay
The safety and efficacy of Australian tickborne disease vaccine strains in cattle in Paraguay
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DOI：
10.1016/s0304-4017(97)00047-2
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发表时间：
1998-03-31
影响因子：
2.6
通讯作者：
Ortigosa, D
中科院分区：
文献类型：
--
作者：
Brizuela, CM;Ortellado, CA;Ortigosa, D
将澳大利亚开发的甘油保存的冷冻蜱传疾病疫苗株进口到巴拉圭，以测试其在怀孕的 Holando 小母牛中的安全性，以及在赫里福德 x Criolla 小母牛中测试其对抗当地接种的二联巴贝虫、牛巴贝虫和边缘无形体菌株攻击的功效。这两种巴贝虫菌株被证明是安全的，而牛巴贝虫 K 菌株在为当地牛巴贝虫菌株提供免疫力方面非常有效。 B. bigemina 功效试验尚无定论，可能是由于用于攻击的当地现场菌株无毒。中央曲霉菌株在安全性试验中并未被证明具有理想的安全性，在功效试验中也没有提供与巴贝虫菌株一样好的保护作用。结论是，巴贝虫菌株在巴拉圭提供了针对田间挑战的良好保护，并且可以安全地用于高度易感的牛，但是应该寻找中央巴贝虫菌株的替代品来提供针对边缘巴贝虫菌株的保护。 (C) 1998 Elsevier Science B.V.
Glycerol preserved, frozen tick-borne disease vaccine strains developed in Australia were imported into Paraguay to test their safety in pregnant Holando heifers and their efficacy against challenge from inoculated local field strains of Babesia bigemina, B. bovis and Anaplasma marginale in Hereford x Criolla heifers. The two Babesia strains proved to be safe and the B. bovis K strain was very effective in providing immunity to a local field strain of B. bovis. The B. bigemina efficacy trial was inconclusive, possibly due to the avirulent nature of the local field strain used in challenge. The A. centrale strain did not prove to be as safe as would be desirable in safety trials, neither did it provide as good protection as the Babesia strains in the efficacy trial. It was concluded that the Babesia strains provided good protection against field challenge in Paraguay and were safe to use in highly susceptible cattle, however an alternative to A. centrale should be sought to provide protection against local strains of A. marginale. (C) 1998 Elsevier Science B.V.