Acute withdrawal of short-term or prolonged L-triiodothyronine administration to thyroidectomized rats results in similar rapid increases in TSH beta mRNA.
Acute withdrawal of short-term or prolonged L-triiodothyronine administration to thyroidectomized rats results in similar rapid increases in TSH beta mRNA.
复制标题
对甲状腺切除大鼠短期或长期给予 L-三碘甲状腺原氨酸的急性戒断会导致 TSH β mRNA 类似的快速增加。
DOI：
10.1007/bf03349534
复制
发表时间：
1990
影响因子：
5.4
通讯作者：
Cohen,A
中科院分区：
文献类型：
--
作者：
Ross,DS;Cohen,A
In pian, following the treatment of hyperthyroidism, or the withdrawal of prolonged suppressive thyroid hormone therapy, recovery from thyrotrope suppression may not occur until thyroid hormone concentrations have been subnormal for several weeks. Short-term studies in rodents have demonstrated a rapid increase in TSH synthesis after the acute withdrawal of thyroid hormones. We treated thyroidectomized rats with supraphysiologic doses of 1-triiodothyronine (T3) for 67 days, then abruptly withdrew treatment and compared the time course of thyrotrope recovery to that in animals given T3for only 10 days. Increases in TSHβ mRNA after abruptly stopping T3were qualitatively similar in both groups. After short-term T3administration, TSHβ mRNA was detectable on the second day after stopping T3administration and rose an additional 10-fold by day 5. After prolonged T3administration, TSHβ mRNA was barely detectable on the second day after stopping T3administration, clearly detectable on the third day, and increased an additional 20-fold by day 7. Compared to animals who received T3for only 10 days, suppression of the thyrotrope by T3administration for 67 days resulted in a nonsignificant delay in TSHβ mRNA synthesis of 24 h or less following the abrupt withdrawal of thyroid hormone. It is possible that differences in rat and human thyrotrope responsiveness account for the apparently different biologic behavior.
