Colchicine and the Heart Pushing the Envelope
Colchicine and the Heart Pushing the Envelope
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DOI：
10.1016/j.jacc.2013.08.726
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发表时间：
2013-11-12
影响因子：
24
通讯作者：
Stefanadis, Christodoulos
中科院分区：
文献类型：
--
作者：
Deftereos, Spyridon;Giannopoulos, Georgios;Stefanadis, Christodoulos
秋水仙碱是一种天然的古老药物，至今仍在使用，传统上被认为是痛风的主要治疗方法和心包炎的二线治疗方法，也是家族性地中海热和白塞氏病管理的基本组成部分。它通常被归类为抗炎药，尽管其作用机制不涉及受非类固醇抗炎药和糖皮质激素影响的花生四烯酸途径。秋水仙碱通过与微管蛋白结合抑制微管聚合，从而影响任何需要细胞骨架变化的过程，包括细胞有丝分裂和中性粒细胞运动。最近的研究表明，秋水仙碱可能被证明是有用的心血管疾病比以前怀疑更广泛的频谱，重新点燃了对这种老药的兴趣。在这篇综述中，我们简要介绍了秋水仙碱的生化特性，作用机制和副作用，以及检查目前已知的有前途的作用，秋水仙碱在心血管药物超越心包疾病。(C)2013年美国心脏病学会基金会
Colchicine, a natural and ancient drug still used today, is traditionally considered the staple therapy for gout and a second-line treatment for pericarditis, as well as a basic part of familial Mediterranean fever and Behcet's disease management. It is commonly classified as an anti-inflammatory agent, although its mechanism of action does not involve the arachidonic acid pathway affected by non-steroid anti-inflammatory drugs and glucocorticoids. Colchicine inhibits microtubule polymerization by binding to tubulin, thus affecting any process that requires cytoskeletal changes, including cell mitosis and neutrophil motility. Recent studies suggest that colchicine may prove to be useful in a much wider spectrum of cardiovascular diseases than previously suspected, rekindling the interest in this old drug. In this review we briefly present the biochemical characteristics, mechanism of action and side-effects of colchicine, as well as examine what is currently known about the promising role of colchicine in cardiovascular medicine beyond pericardial disease. (C) 2013 by the American College of Cardiology Foundation