A hub for ABA signaling to the nucleus: significance of a cytosolic and nuclear dual-localized PPR protein SOAR1 acting downstream of Mg-chelatase H subunit.
A hub for ABA signaling to the nucleus: significance of a cytosolic and nuclear dual-localized PPR protein SOAR1 acting downstream of Mg-chelatase H subunit.
复制标题
ABA 信号传导到细胞核的枢纽：胞浆和细胞核双定位 PPR 蛋白 SOAR1 作用于镁螯合酶 H 亚基下游的意义。
DOI：
10.4161/15592316.2014.972899
复制
发表时间：
2014
影响因子：
2.9
通讯作者：
Zhang DP
中科院分区：
文献类型：
--
作者：
Jiang SC;Mei C;Wang XF;Zhang DP
SOAR1是一种细胞质-细胞核双定位的五肽重复（PPR）蛋白，我们最近发现它是CHLH/ABAR （mg螯合酶H亚基/推定的ABA受体）介导的信号通路的关键调节因子，作用于CHLH/ABAR的下游和核ABA响应的bZIP转录因子ABI5的上游。SOAR1表达的下调和上调显著改变了ABA敏感性和核心ABA应答基因亚群的表达，表明SOAR1是ABA向细胞核信号传导的枢纽，CHLH/ABAR介导了通过SOAR1调控下游基因表达的中枢信号通路。
SOAR1 is a cytosol-nucleus dual-localized pentatricopeptide repeat (PPR) protein, which we indentified recently as a crucial regulator in the CHLH/ABAR (Mg-chelatase H subunit /putative ABA receptor)-mediated signaling pathway, acting downstream of CHLH/ABAR and upstream of a nuclear ABA-responsive bZIP transcription factor ABI5. Downregulation and upregulation of SOAR1 expression alter dramatically both ABA sensitivity and expression of a subset of key, nuclear ABA-responsive genes, suggesting that SOAR1 is a hub for ABA signaling to the nucleus, and CHLH/ABAR mediates a central signaling pathway to regulate downstream gene expression through SOAR1.