EFFECTS OF MELATONIN ON SLEEP AND NEUROCHEMISTRY IN THE RAT
EFFECTS OF MELATONIN ON SLEEP AND NEUROCHEMISTRY IN THE RAT
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DOI：
10.1111/j.1476-5381.1982.tb09194.x
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发表时间：
1982-01-01
影响因子：
7.3
通讯作者：
SUGDEN, D
中科院分区：
文献类型：
--
作者：
HOLMES, SW;SUGDEN, D
1采用脑电图记录和标准荧光技术研究了腹腔注射褪黑素对大鼠睡眠和脑神经化学的影响。2褪黑激素10 mg/kg可减少入睡时间和清醒时间，但增加慢波睡眠和异相睡眠。2.5 mg/kg剂量产生了类似但较小的影响。3.褪黑激素的剂量都没有改变正常的脑电图模式或扰乱正常的睡眠行为。4褪黑激素，20毫克/公斤，没有显着改变色氨酸，5-羟色胺，5-羟吲哚乙酸，去甲肾上腺素或多巴胺在大脑的任何部分的浓度。结论：褪黑激素的睡眠促进活性与脑内吲哚胺和儿茶酚胺水平的总体变化无关。
1 The effects of intraperitoneally administered melatonin on sleep and brain neurochemistry in the rat were studied by use of EEG recording and standard fluorescence techniques. 2 Melatonin, 10 mg/kg, reduced time to sleep onset and time spent awake but increased both slow wave and paradoxical sleep. Qualitatively similar but smaller effects were produced by a dose of 2.5 mg/kg. 3 Neither dose of melatonin altered normal EEG patterns or disrupted normal sleep behaviour. 4 Melatonin, 20 mg/Kg, did not significantly alter concentrations of tryptophan, 5-hydroxytryptamine, 5-hydroxyindoleacetic acid, noradrenaline or dopamine in any part of the brain. 5 it is concluded that the sleep promoting activity of melatonin cannot be related to gross changes in brain indoleamine and catecholamine levels.