MOUSE TERATOLOGY STUDIES WITH CHLORODIBENZO-P-DIOXINS
MOUSE TERATOLOGY STUDIES WITH CHLORODIBENZO-P-DIOXINS
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DOI：
10.1007/bf01685572
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发表时间：
1976-01-01
影响因子：
2.7
通讯作者：
COURTNEY, KD
中科院分区：
文献类型：
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作者：
COURTNEY, KD
研究人员将2,3,7,8-四氯二苯并-对二恶英（TCDD）等多氯二苯并-对二恶英（TCDD）每日口服和皮下注射给妊娠组和非妊娠组雌性小鼠。所研究的化合物中没有一种对TCDD具有毒性，而且致畸效应仅限于该化合物，87%的异常胎儿/产仔是由最低皮下剂量（25 μ g/kg天）引起的。建议皮下注射TCDD比口服给药更容易获得生物。得出的结论是，与TCDD相比，所研究的其他二苯并-对二恶英相对无毒，并且在使用的剂量下，不会致畸。
Polychlorinated dibenzo-p-dioxins including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were administered daily orally and subcutaneously to groups of pregnant and non-pregnant female mice. None of the compounds studied were as toxic to TCDD and teratological effects were confined to this compound, 87% of abnormal foetuses/litter resulting from the lowest subcutaneous dose employed (25 mu g/kg day). It is suggested that TCDD injected subcutaneously is more readily available biologically than when administered orally. It is concluded that compared with TCDD the other dibenzo-p-dioxins studied are relatively non-toxic and, at the doses employed, not teratogenic.