BILE-SALTS, HYPOTENSION AND OBSTRUCTIVE-JAUNDICE
BILE-SALTS, HYPOTENSION AND OBSTRUCTIVE-JAUNDICE
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DOI：
10.1042/cs0670177
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发表时间：
1984-01-01
期刊：
影响因子：
6
通讯作者：
BETTER, OS
中科院分区：
文献类型：
--
作者：
BOMZON, A;FINBERG, JPM;BETTER, OS
胆管结扎对血管和血管外平滑肌对去甲肾上腺素和酪胺的反应性的影响进行了研究，使用离体大鼠后肢灌注和门静脉和输精管的准备。胆管结扎可降低血管和血管外平滑肌对去甲肾上腺素的收缩反应。平滑肌暴露于某些胆汁盐导致收缩力降低。这种效应依赖于胆盐的类型和浓度。这些体外研究表明，在阻塞性黄疸中观察到的总外周阻力降低和低血压不能用某些胆盐对平滑肌的痉挛作用来解释。
The effects of bile duct ligation on vascular and extravascular smooth muscle responsiveness to noradrenaline [norepinephrine] and tyramine were examined using isolated rat hindlimb perfusion and portal vein and vas deferens preparations. Bile duct ligation reduced the contractile responses to noradrenaline of vascular and extravascular smooth muscle. Exposure of smooth muscle to some bile salts caused a reduction in contractility. This effect was dependent upon bile salt type and concentration. These studies in vitro suggest that the reduced total peripheral resistance and hypotension seen in obstructive jaundice cannot be explained by a spasmolytic effect of some of the bile salts on smooth muscle.