Sequence of the latency-related gene of herpes simplex virus type 1.
Sequence of the latency-related gene of herpes simplex virus type 1.
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1型单纯疱疹病毒潜伏期相关基因的序列。
DOI：
10.1016/0042-6822(89)90416-9
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发表时间：
1989
期刊：
影响因子：
3.7
通讯作者：
Ghiasi,H
中科院分区：
文献类型：
--
作者：
Wechsler,SL;Nesburn,AB;Zwaagstra,J;Ghiasi,H
单纯疱疹病毒1型在神经元中潜伏期间，RNA从病毒基因组的一个小区域转录。这种潜伏期相关RNA（LR RNA）与立即早期基因ICPO的mRNA反义，与ICPO mRNA部分重叠，并被怀疑在帮助维持潜伏期方面发挥某种作用。我们在这里报告的潜伏相关基因（LR基因）的序列和它的侧翼序列从菌株F，并将其与该区域的可用部分序列从菌株17 syn+和科斯。两个潜在的开放阅读框架（ORF）是共同的所有三个序列。序列分析表明启动子可能位于LR基因的两个不同区域。
During herpes simplex virus type 1 latency in neurons, RNA is transcribed from one small region of the viral genome. This latency-related RNA (LR RNA) is antisense to the mRNA of the immediate early gene ICPO, partially overlaps the ICPO mRNA, and is suspected of playing some role in helping maintain latency. We report here the sequence of the latency-related gene (LR gene) and its flanking sequences from strain F, and compare it to the available partial sequences of this region from strains 17 syn+and KOS. Two potential open reading frames (ORFs) were common to all three sequences. Sequence analysis suggested the possibility of promoters in two different regions of the LR gene.