Trained versus untrained men: Different immediate post-exercise responses of pituitary adrenal axis - A preliminary study
Trained versus untrained men: Different immediate post-exercise responses of pituitary adrenal axis - A preliminary study
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DOI：
10.1007/s004210050170
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发表时间：
1997-04-01
期刊：
影响因子：
--
通讯作者：
Manier, G
中科院分区：
文献类型：
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作者：
Duclos, M;Corcuff, JB;Manier, G
下丘脑-垂体-肾上腺轴参与整个运动-恢复周期。然而，久坐和耐力训练的受试者在早期恢复期间激素反应的差异尚不清楚。这项初步研究的目的是监测四名耐力训练的成年人（马拉松男子）在跑步运动期间和结束后的血浆皮质醇和促肾上腺皮质激素（ACTH）浓度，并与四名久坐不动的受试者进行比较。连续4天改变强度和持续时间两个参数。第1（st）天（D-0）在实验室度过：在休息时采集所有血液样本，以确定每种激素的日变化。在接下来的几天（D-1-D-4），受试者进行D1和D2短时间运动（20分钟），轻度运动（50%最大心率HRmax， D-1）或剧烈运动（80%最大心率HRmax， D-2）， D-3和D-4长时间运动（120分钟），轻度运动（D-3）或剧烈运动（D-4）。在两组中，短暂运动（D-1, D-2）和长时间轻度运动（D-3）均未引起血浆ACTH或皮质醇浓度的显著变化。血浆ACTH和皮质醇浓度只有在高强度和长时间运动时才会升高（D-4）。在我们的实验条件下，训练因素并没有改变垂体-肾上腺皮质对运动反应激活的强度或持续时间阈值。然而，在从四种运动方案中立即恢复的过程中，马拉松男性的血浆ACTH浓度不断高于久坐受试者，尽管两组的血浆皮质醇浓度保持相似。作为评估ACTH和皮质醇之间关系的间接手段，我们同时比较了从D-1到D-4与D-0恢复期间0.5至3.5h皮质醇和ACTH曲线下面积（AUG）。久坐受试者和马拉松男性的皮质醇AUC相似，但ACTH AUC在久坐受试者和马拉松男性中不同，提示垂体-肾上腺关系在某种程度上发生了变化，但尚不确定。在运动后立即恢复的过程中，无论运动强度如何，ACTH反应的强度在训练对象中都有所增加，但对其目标肾上腺的影响却有所减少。这一现象在文献中没有描述过。可能涉及两种非排他性现象，即肾上腺对ACTH刺激的敏感性降低，和/或下丘脑-垂体轴对皮质醇负反馈的敏感性降低。
The hypothalamo-pituitary-adrenal axis is involved throughout the exercise-recovery cycle. Nevertheless, differences in hormone responses during early recovery between sedentary and endurance trained subjects are not well known. The aim of this preliminary study was to monitor plasma cortisol and adrenocorticotropic hormone (ACTH) concentrations both during and after the end of running exercise performed by four endurance trained adults (marathon men) compared to four sedentary subjects. Two parameters, i.e. intensity and duration, were changed on 4 consecutive days. The 1(st) day (D-0) was spent in the laboratory: all blood samples were obtained at rest to determine diurnal variations of each hormone. On the following days (D-1-D-4) the subjects exercised: D1 and D2 brief (20 min), light (50% maximal heart rate HRmax, D-1) or strenuous (80% HRmax, D-2), D-3 and D-4 prolonged (120 min), light (D-3) or strenuous (D-4) In both groups, neither brief (D-1, D-2) nor prolonged light exercise (D-3) induced any significant variation in plasma ACTH or cortisol concentrations. Plasma ACTH and cortisol concentrations increased only if the exercise was intense and prolonged (D-4) The training factor did not modify the intensity or duration thresholds for the activation of the pituitary-adrenocortical response to exercise in the conditions of our experiment. However, during immediate recovery from the four exercise regimens, the plasma ACTH concentrations of the marathon men were constantly above the values of the sedentary subjects, although plasma cortisol concentration remained similar in both groups. As an indirect means of evaluating the relationships between ACTH and cortisol we compared the areas under the cortisol and ACTH curves (AUG) from 0.5 to 3.5h during recovery from D-1 to D-4 compared to D-0 at the same time. Cortisol AUC were similar in the sedentary subjects and marathon men although the ACTH AUC were different in the sedentary subjects and marathon men, suggesting a change in the pituitary-adrenal relationship at some yet indeterminate level. During the immediate recovery from exercise whatever its intensity, the magnitude of the ACTH response was increased in the trained subjects but with a reduced effect upon its target, the adrenal glands. This phenomenon has not been described in the literature. Two non-exclusive phenomena may be involved, i.e. a decreased adrenal sensitivity to ACTH stimulation, and/or a decreased hypothalamo-pituitary axis sensitivity to cortisol negative feedback.