Rare Ha‐ras and c‐mos alleles in patients with intracranial tumors
Rare Ha‐ras and c‐mos alleles in patients with intracranial tumors
复制标题
颅内肿瘤患者中罕见的 Ha-ras 和 c-mos 等位基因
DOI：
10.1212/wnl.38.4.587
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发表时间：
1988
期刊：
影响因子：
9.9
通讯作者：
J. Schmidtke
中科院分区：
文献类型：
--
作者：
U. Diedrich;Ottmar Eckermann;J. Schmidtke
白细胞DNA中罕见的高变Ha-ras等位基因或罕见的c-mos等位基因的出现被认为与癌症易感性有关。我们分析了一组颅内肿瘤患者，以确定Ha-ras位点和c-mos位点的罕见等位基因的发生率是否比正常人增加。我们发现患者中罕见的高变Ha-ras等位基因（9.5%至3%）和5千碱基EcoRI c-mos等位基因（2.5%至0%）的发生率较高。这些结果与这种不寻常的等位基因与颅内肿瘤易感性相关的观点是一致的。
The occurrence of rare hypervariable Ha-ras alleles or of a rare c-mos allele in white blood cell DNA is claimed to be associated with susceptibility to cancer. We analyzed a group of patients with intracranial tumors to determine whether the occurrence of rare alleles at the Ha-ras locus and at the c-mos locus was increased in comparison with normal individuals. We found a higher incidence of rare hypervariable Ha-ras alleles (9.5% to 3%) and a 5 kilobase EcoRI c-mos allele (2.5% to 0%) in the patients. These results are consistent with the opinion that such unusual alleles are associated with a predisposition to intracranial tumors.