Captopril inhibits tumour growth in a xenograft model of human renal cell carcinoma.
Captopril inhibits tumour growth in a xenograft model of human renal cell carcinoma.
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卡托普利在人肾细胞癌的异种移植模型中抑制肿瘤生长。
DOI：
10.1038/bjc.1998.145
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发表时间：
1998-03
影响因子：
8.8
通讯作者：
Jonsson, JR
中科院分区：
文献类型：
--
作者：
Hii, SI;Nicol, DL;Gotley, DC;Thompson, LC;Green, MK;Jonsson, JR
卡托普利对人肾细胞癌（RCC）异种移植模型肿瘤生长的影响进行了研究。在严重联合免疫缺陷（SCID）小鼠左肾囊下接种人肾细胞癌细胞系SN12K-1（10(6)个细胞），可导致大肿瘤生长，与对侧正常肾脏相比，接种后的肾脏重量增加3.69+/-1.63倍（平均+/-s.d）。在用卡托普利（19 mg kg（-1）天）或94 mg kg（-1）天（-1）饮用水治疗的小鼠中，肿瘤发展有显著的剂量相关的减少；荷瘤组肾脏重量分别为正常肾脏的1.9+/-0.42倍和1.55+/-0.42倍（与未治疗组比较P< 0.05）。在体外，临床可达到的剂量（0.1-10微米）卡托普利对[3H]胸苷在SN12K-1细胞内的掺入无显著影响。因此，卡托普利对体内肿瘤生长的这种高度显著的衰减似乎不是由于对肿瘤细胞增殖的直接影响。需要进一步的研究来确定卡托普利抑制肿瘤生长的机制，特别是评估血管紧张素II在这一过程中的作用。
The effect of captopril on tumour growth was examined in a xenograft model of human renal cell carcinoma (RCC). Inoculation of the human RCC cell line SN12K-1 (10(6) cells) under the left kidney capsule of severe combined immunodeficient (SCID) mice resulted in the growth of large tumours, with an increase in weight of the inoculated kidney of 3.69+/-1.63-fold (mean+/-s.d.) when compared with the contralateral normal kidney. In mice treated with captopril (19 mg kg(-1) day(-1) or 94 mg kg(-1) day(-1) administered in the drinking water), there was a significant dose-related reduction in tumour development; the tumour bearing kidneys weighed 1.9+/-0.42 and 1.55+/-0.42 times the normal kidneys, respectively (P< 0.05 compared with untreated animals). In vitro, captopril at clinically achievable doses (0.1-10 microM) had no significant effect on the incorporation of [3H]thymidine into SN12K-1 cells. Thus, this highly significant attenuation by captopril of in vivo tumour growth does not appear to be due to a direct effect on the proliferation of the tumour cells. Further studies are required to determine the mechanism of inhibition of tumour growth by captopril, in particular to evaluate the role of angiotensin II in this process.
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影响因子：
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作者：
GOLIGORSKY, MS;OSBORNE, D;KARL, IE
通讯作者：
KARL, IE
影响因子：
158.5
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15.9
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Bouck, NP
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通讯作者：
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通讯作者：
JULIN, CM