Short-term buprenorphine maintenance: Treatment outcome
Short-term buprenorphine maintenance: Treatment outcome
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DOI：
10.1300/j069v22n03_04
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发表时间：
2003-01-01
影响因子：
2.3
通讯作者：
Neumann, E
中科院分区：
文献类型：
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作者：
Galanter, M;Dermatis, H;Neumann, E
52名海洛因成瘾者在精神科住院医师的护理下接受丁丙诺啡治疗，环境以办公室实践为模型。受试者维持16 mg每日给药6周的方案，然后逐渐减少至零剂量直至第16周，并维持安慰剂直至第18周。在首次诱导给药后继续接受治疗的44例受试者中，11例在维持治疗期间终止，17例在逐渐减量期间终止，16例在零剂量时终止。每周两次的尿液毒理学结果显示，在这三个时期，海洛因使用阳性的样本分别显著连续下降：70%、41%和20%。在历史变量中，仅既往AA访视区分了达到零剂量的受试者和未达到零剂量的受试者。与最近的研究相比，相对缺乏经验的办公室医生可以将患者的丁丙诺啡维持在与研究诊所环境报告的水平相当的水平，但海洛因戒断率相当。根据基于办公室的阿片类药物维持的潜在选择，对这些结果进行了讨论。(C)出版社：The Haworth Press，Inc. All rights reserved.
Fifty-two heroin addicts were inducted onto buprenorphine under the care of psychiatric residents in a setting modeled on office practice. Subjects were maintained on a protocol of six weeks of 16 mg daily dosing, then tapered to zero dose up to week 16, and maintained on placebo through week 18. Of 44 subjects who continued after the first induction dose, 11 terminated during maintenance, 17 during taper; and 16 while on zero dose. Twice weekly urine toxicologies showed significant successive declines in samples positive for heroin use across these three periods: 70%, 41%, and 20%, respectively. Among historical variables, only prior AA attendance distinguished subjects who achieved zero dose from those who did not. A comparison with recent studies suggests that relatively inexperienced office-based physicians can maintain patients on buprenorphine at a level comparable to that reported for research clinic settings, but with comparable rates of heroin abstinence. These findings are discussed in light of potential options for office-based opioid maintenance. (C) 2003 by The Haworth Press, Inc. All rights reserved.