Increased disease severity in non-Western immigrants with multiple sclerosis in Oslo, Norway
Increased disease severity in non-Western immigrants with multiple sclerosis in Oslo, Norway
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DOI：
10.1111/ene.12227
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发表时间：
2013-12-01
影响因子：
5.1
通讯作者：
Celius, E. G.
中科院分区：
文献类型：
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作者：
Berg-Hansen, P.;Smestad, C.;Celius, E. G.
背景和目的挪威的非西方移民在移民后患多发性硬化症（MS）的风险增加。种族和脑脊液 (CSF) 中寡克隆带 (OCB) 的存在可能会影响病程。本研究的目的是调查挪威裔和移民多发性硬化症患者的疾病严重程度和 OCB 存在情况的差异。方法将 47 名非西方移民多发性硬化症患者的临床数据和脑脊液检查结果与 447 名挪威人和 48 名西方国家移民患者的临床数据和脑脊液检查结果进行比较。结果非西方移民的平均多发性硬化症严重程度评分 (MSSS) 高于挪威患者（5.68 比 4.13， P=0.001）。非西方移民的发病年龄低 4 岁（P=0.001）。调整出生年份、发病年龄、性别和病程后，各组之间的 MSSS 平均差异为 2.17（P
Background and purposeNon-Western immigrants to Norway acquire an increased risk of multiple sclerosis (MS) after migration. Ethnicity and the presence of oligoclonal bands (OCBs) in the cerebrospinal fluid (CSF) might influence the disease course. The aim of this study was to investigate differences in disease severity and in the presence of OCBs in ethnic Norwegian and immigrant MS patients.MethodsClinical data and CSF findings from 47 non-Western immigrants with MS were compared with those from 447 Norwegian and 48 immigrant patients from Western countries.ResultsThe non-Western immigrants had a higher mean Multiple Sclerosis Severity Score (MSSS) than the Norwegian patients (5.68 vs. 4.13, P=0.001). Age at onset was 4years lower amongst the non-Western immigrants (P=0.001). After adjusting for year of birth, age at onset, gender and disease course, the mean difference in MSSS between the groups was 2.17 (P