Development and physiological regulation of intestinal lipid absorption.: III.: Intestinal transporters and cholesterol absorption
Development and physiological regulation of intestinal lipid absorption.: III.: Intestinal transporters and cholesterol absorption
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DOI：
10.1152/ajpgi.00061.2008
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发表时间：
2008-04-01
影响因子：
4.5
通讯作者：
Howles, Philip N.
中科院分区：
文献类型：
--
作者：
Hui, David Y.;Labonte, Eric D.;Howles, Philip N.
肠道胆固醇的吸收受肠道细胞内转运蛋白的调节。从肠腔摄取胆固醇需要顶端刷状缘膜上的几种蛋白质，包括Niemann-Pick C1-like 1(NPC1L1)、清道夫受体B-I和CD36，而顶膜上的两个ATP结合盒半转运体ABCG5和ABCG8共同作用，将胆固醇流出到肠腔，以限制胆固醇的吸收。NPC1L1对于胆固醇的吸收是必不可少的，但它作为细胞表面转运蛋白或细胞内胆固醇转运蛋白的功能还需要澄清。另一种三磷酸腺苷转运体ABCA1存在于肠上皮细胞的基底膜上，介导高密度脂蛋白的分泌。
Intestinal cholesterol absorption is modulated by transport proteins in enterocytes. Cholesterol uptake from intestinal lumen requires several proteins on apical brush-border membranes, including Niemann-Pick C1-like 1 (NPC1L1), scavenger receptor B-I, and CD36, whereas two ATP-binding cassette half transporters, ABCG5 and ABCG8, on apical membranes work together for cholesterol efflux back to the intestinal lumen to limit cholesterol absorption. NPC1L1 is essential for cholesterol absorption, but its function as a cell surface transporter or an intracellular cholesterol transport protein needs clarification. Another ATP transporter, ABCA1, is present in the basolateral membrane to mediate HDL secretion from enterocytes.