Asprosin: a novel peptide hormone related to insulin resistance in women with polycystic ovary syndrome
Asprosin: a novel peptide hormone related to insulin resistance in women with polycystic ovary syndrome
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DOI：
10.1080/09513590.2018.1512967
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发表时间：
2019-03-04
影响因子：
2
通讯作者：
Taner, Cuneyt Eftal
中科院分区：
文献类型：
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作者：
Alan, Murat;Gurlek, Beril;Taner, Cuneyt Eftal
白色脂肪肽是一种新发现的与胰岛素抵抗相关的肽类激素。该肽促进肝葡萄糖产生。多囊卵巢综合征（PCOS）是一种常见的卵巢疾病。胰岛素抵抗在该病的发病机制中起着至关重要的作用。本研究旨在探讨多囊卵巢综合征患者胰岛素抵抗与白色脂肪肽的关系。我们招募了78名PCOS患者和78名年龄匹配和体重指数（BMI）匹配的对照者进入这项横断面研究。使用ELISA方法验证循环白色脂肪肽水平。我们还确定了代谢和激素参数的参与主题。我们发现PCOS患者的循环中白色脂肪肽水平高于对照组。阿司匹林水平与胰岛素抵抗、BMI和游离雄激素指数（FAI）呈正相关。此外，与具有最低三分位白色脂肪肽水平的那些受试者相比，具有最高三分位白色脂肪肽水平的受试者表示患有PCOS的几率增加。白色脂肪肽水平升高导致PCOS风险与胰岛素抵抗相关的可能性增加。
Asprosin associated with insulin resistance is a newly discovered peptide hormone. The peptide promotes hepatic glucose production. Polycystic ovary syndrome (PCOS) is a metabolic disorder. Insulin resistance plays a vital role in the pathogenesis of the disease. The aim of this study was to discover the association between insulin resistance and asprosin in women with PCOS. We recruited 78 subjects with PCOS and 78 age-matched and body mass index (BMI)-matched controls into this cross-sectional study. Circulating asprosin levels were validated using ELISA method. We also determined metabolic and hormonal parameters of the involved subjects. We found that circulating asprosin levels were elevated in women with PCOS with respect to controls. Asprosin levels showed a positive correlation with insulin resistance, BMI, and free androgen index (FAI). Moreover, subjects with the highest tertile of asprosin levels represented increased odds of having PCOS as compared to those subjects with the lowest tertile asprosin levels. Increased asprosin levels resulted to high possibility of having PCOS risk associated with insulin resistance.