Homeostasis model assessment of insulin resistance and outcome of ischemic stroke in non-diabetic patients - a prospective observational study
Homeostasis model assessment of insulin resistance and outcome of ischemic stroke in non-diabetic patients - a prospective observational study
复制标题
DOI：
10.1186/s12883-019-1406-3
复制
发表时间：
2019-07-25
期刊：
影响因子：
2.6
通讯作者：
Svensson, Johan
中科院分区：
文献类型：
--
作者：
Aberg, Daniel;Aberg, N. David;Svensson, Johan
BackgroundInsulin resistance（IR）与糖尿病相关是缺血性卒中（IS）的危险因素，而对非糖尿病IR和IS后的结局知之甚少。MethodsIn非糖尿病IS（n=441）和对照组（n=560）来自Sahloska Academy缺血性卒中研究（SAHLSIS），IR与IS严重程度和功能结局相关。采用胰岛素抵抗稳态模型（HOMA-IR）评价急性期和3个月后的胰岛素抵抗。采用美国国立卫生研究院卒中量表（NIHSS）评估卒中严重程度。采用改良兰金量表（mRS）评价术后3个月、2年、7年的功能结局。结果与对照组相比，IS组急性和3个月HOMA-IR均显著升高（P
BackgroundInsulin resistance (IR) in relation to diabetes is a risk factor for ischemic stroke (IS), whereas less is known about non-diabetic IR and outcome after IS.MethodsIn non-diabetic IS (n=441) and controls (n=560) from the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS), IR was investigated in relation to IS severity and functional outcome. IR was evaluated acutely and after 3months using the Homeostasis model assessment of IR (HOMA-IR). Stroke severity was assessed by the National Institutes of Health Stroke Scale (NIHSS). Functional outcome was evaluated using the modified Rankin Scale (mRS) after 3months, 2 and 7years. Associations were evaluated by logistic regression.ResultsHigher acute and 3-month HOMA-IR was observed in IS compared to the controls (both p