Organocatalysis in radical chemistry.: Enantioselective α-oxyamination of aldehydes
Organocatalysis in radical chemistry.: Enantioselective α-oxyamination of aldehydes
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DOI：
10.1021/ja069245n
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发表时间：
2007-04-11
影响因子：
15
通讯作者：
Hasegawa, Masayuki
中科院分区：
文献类型：
--
作者：
Sibi, Mukund P.;Hasegawa, Masayuki
我们使用手性有机催化剂开发了一种有效的自由基α-氧胺化反应。该反应可以使用廉价的 SET 试剂进行，并且已经建立了相当广泛的底物范围。使用 20 mol% 的催化剂获得了 α-氧化产物的良好至高对映选择性。这项工作中报道的方法增加了可以使用有机催化剂进行的不对称自由基反应的范围。
We have developed an efficient radical alpha-oxyamination reaction using chiral organocatalysts. The reaction can be carried out with inexpensive SET reagents, and a reasonably broad substrate scope has been established. Good to high enantioselectivity for the alpha-oxygenated products are obtained using 20 mol % of the catalyst. The methodology reported in this work adds to the repertoire of asymmetric radical reactions that can be conducted using organocatalysts.