(+)- and (-)-ganodilactone, a pair of meroterpenoid dimers with pancreatic lipase inhibitory activities from the macromycete Ganoderma leucocontextum
(+)- and (-)-ganodilactone, a pair of meroterpenoid dimers with pancreatic lipase inhibitory activities from the macromycete Ganoderma leucocontextum
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DOI：
10.1039/c6ra10638b
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发表时间：
2016-01-01
期刊：
影响因子：
3.9
通讯作者：
Liu, Ji-Kai
中科院分区：
文献类型：
--
作者：
Chen, He-Ping;Zhao, Zhen-Zhu;Liu, Ji-Kai
（+）-和（-）-Ganodilactone（1）是从白缘灵芝（Ganoderma leucocontextum）子实体中发现的一对具有独特的5 'H-螺[色满-4，2'-呋喃]-2，5 '-二酮环系统的新的部分萜二聚体，沿着它们的生物学相关化合物ganomycin I（2）。通过1D和2D NMR谱、HRESIMS分析和ECD计算，对化合物的结构和绝对构型进行了归属。（+/-）-、（+）-和（-）-ganodilactone（1）显示出胰脂肪酶抑制活性，并显示出IC 50值分别为27.3、4.0和2.5 μ M。
(+)- and (-)-Ganodilactone (1), a pair of novel meroterpenoid dimers possessing a unique 5'H-spiro [chroman-4,2'-furan]-2,5'-dione ring system, along with their biogeneticly-related compound, ganomycin I (2), were discovered from the fruiting bodies of Ganoderma leucocontextum. The structures and absolute configurations were assigned with the aid of 1D and 2D NMR spectra, HRESIMS analysis and ECD calculations. (+/-)-, (+)-, and (-)-ganodilactone (1) showed pancreatic lipase inhibitory activities and exhibited the IC50 values as 27.3, 4.0, and 2.5 mu M, respectively.