Neuromuscular characterization of the urethra in continent women.
Neuromuscular characterization of the urethra in continent women.
复制标题
DOI：
10.1097/spv.0b013e31822dd012
复制
发表时间：
2011-09
影响因子：
1.6
通讯作者：
Brubaker L
中科院分区：
文献类型：
--
作者：
Kenton K;Mueller E;Brubaker L
描述不同种族的大陆妇女的尿道功能参数。在机构审查委员会批准后，我们从社区招募了没有尿失禁的女性。被认为是大陆，参与者回答“从来没有”的前六个问题的压力分量表的医疗，流行病学和社会方面的老龄化尿失禁（梅萨）问卷。所有参与者均接受定量同心性尿道肌电图（EMG）和尿动力学测试（UDS）。31名平均±SD年龄为39±14岁的女性接受了EMG和UDS。该队列具有种族多样性，包括13名白人（43%），13名非洲裔美国人（43%）和4名西班牙裔（14%）。体重指数（BMI）（P= 0.12，0.06）、年龄（P= 0.40，0.64）和阴道产次（P= 0.53，0.76）在人种或种族之间没有差异。我们没有检测到任何EMG参数的种族，民族或阴道产次的差异。在Multi-MUP分析中识别并分析了30个运动单位动作电位分析（MUP）（10-55）的平均值（范围），在IP分析中识别并分析了14个（8-21）。平均而言，37±20%的MUP是多相的。年龄与尿道括约肌功能的几项指标显著相关。年龄增加与干扰分析（IP）转数（-0.57，p=.001）、IP振幅（r=-0.43，p=.02）、IP转数/振幅（r=-0.54，p=.003）、最大尿道闭合压（MUCP）（r=-0.41，p=.04）呈负相关。同样，MUCP与IP振幅相关（r= 0.38，p= 0.04）。这一最大的大陆妇女群体的尿道神经肌肉功能数据充分表征了定量尿道肌电图显示出显着的神经病理性MUP随年龄增长的变化。
To describe quantitative urethral function parameters in a racially diverse group of continent women. Following Institutional Review Board approval, we recruited women without urinary incontinence from the community. To be considered continent, participants answered “never” to the first six questions on the stress subscale of the Medical, Epidemiologic, and Social Aspects of Aging urinary incontinence (MESA) questionnaire. Participants all underwent quantitative concentric urethral electromyography (EMG) and urodynamic testing (UDS). Thirty-one women with a mean±SD age of 39±14 years underwent EMG and UDS. The cohort was racially diverse with 13 Caucasians (43%), 13 African Americans (43%), and 4 Hispanics (14%). Body mass index (BMI) (P=.12, .06), age (P=.40, .64), and vaginal parity (P=.53, .76) did not differ by race or ethnicity. We did not detect differences in any EMG parameter by race, ethnicity or vaginally parity. A mean (range) of 30 motor unit action potential analysis (MUP) (10-55) were identified and analyzed in Multi-MUP analysis and 14 (8-21) were identified and analyzed in IP analysis. On average, 37±20% MUPs were polyphasic. Age significantly correlated with several measures of urethral sphincter function. Increasing age was inversely correlated with interference analysis (IP) turns (−.57, p=.001), IP amplitude (r=−.43, p=.02), IP turns/amplitude (r=−.54, p=.003), maximum urethral closure pressures (MUCP) (r=−.41, p=.04). Similarly, MUCP correlated with IP amplitude (r=.38, p=.04). This urethral neuromuscular function data on the largest cohort of continent women fully characterized with quantitative urethral EMG demonstrates significant neuropathic MUP changes with advancing age.