The regulatory function of plasma-membrane Ca2+-ATPase (PMCA) in the heart
The regulatory function of plasma-membrane Ca2+-ATPase (PMCA) in the heart
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DOI：
10.1042/bst0350927
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发表时间：
2007-11-01
影响因子：
3.9
通讯作者：
Neyses, L.
中科院分区：
文献类型：
--
作者：
Oceandy, D.;Stanley, P. J.;Neyses, L.
PMCA（plasma-membrane Ca 2 +-ATPase）是一种广泛表达的钙挤压酶泵，在细胞内钙浓度的控制中起重要作用。与非兴奋性细胞不同，在非兴奋性细胞中，PMCA是唯一的钙外排系统，在兴奋性细胞中，如心肌细胞，与另一种钙外排系统NCX（钠/钙交换器）相比，PMCA在钙稳态中仅起次要作用。然而，越来越多的证据表明PMCA在信号转导中的重要作用;在心脏生理学中特别感兴趣的是PMCA亚型4 b对nNOS（神经元型一氧化氮合酶）的调节。在本文中，我们将讨论支持PMCA 4在调节心脏一氧化氮信号通路中的关键作用的最新进展。
The PMCA (plasma-membrane Ca2+-ATPase) is a ubiquitously expressed calcium-extruding enzymatic pump important in the control of intracellular calcium concentration. Unlike in non-excitable cells, where PMCA is the only system for calcium extrusion, in excitable cells, such as cardiomyocytes, PMCA has been shown to play only a minor role in calcium homoeostasis compared with the NCX (sodium/calcium exchanger), another system of calcium extrusion. However, increasing evidence points to an important role for PMCA in signal transduction; of particular interest in cardiac physiology is the modulation of nNOS (neuronal nitric oxide synthase) by isoform 4b of PMCA. In the present paper, we will discuss recent advances that support a key role for PMCA4 in modulating the nitric oxide signalling pathway in the heart.