Identification of Giardia lamblia Assemblage E in Humans Points to a New Anthropozoonotic Cycle
Identification of Giardia lamblia Assemblage E in Humans Points to a New Anthropozoonotic Cycle
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DOI：
10.1093/infdis/jiw361
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发表时间：
2016-10-15
影响因子：
6.4
通讯作者：
Da-Cruz, Alda M.
中科院分区：
文献类型：
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作者：
Fantinatti, Maria;Bello, Alexandre R.;Da-Cruz, Alda M.
贾第鞭毛虫是一种通过水和食物传播的病原体，在世界范围内引起感染。贾第鞭毛虫基因型分为8个组合（A-H）。在人类中检测到组合A和B，但它们可能是人畜共患的，因为它们感染其他哺乳动物宿主。对44名儿童样本中的贾第鞭毛虫进行了基因分型。对β -栀子苷和谷氨酸脱氢酶编码基因的保守片段进行测序，并与存放在GenBank中的序列比对。与里约热内卢de Janeiro的预期一样，大多数样品与组合a有关，令人惊讶的是，在15个样品中检测到组合E。在人体内检测到E型病毒组合，提示贾第鞭毛虫有一种新的人畜共患传播途径。
Giardia lamblia is a pathogen transmitted by water and food that causes infection worldwide. Giardia genotypes are classified into 8 assemblages (A-H). Assemblages A and B are detected in humans, but they are potentially zoonotic because they infect other mammalian hosts. Giardia in samples from 44 children was genotyped. Conserved fragments of the genes encoding beta-giardin and glutamate dehydrogenase were sequenced and their alignment were carried out with sequences deposited in GenBank. As expected for Rio de Janeiro, the majority of samples were related to assemblage A. Surprisingly, assemblage E was detected in 15 samples. Detection of assemblage E in humans suggests a new zoonotic route of Giardia transmission.