Esophageal OCT Imaging Using a Paddle Probe Externally Attached to Endoscope.
Esophageal OCT Imaging Using a Paddle Probe Externally Attached to Endoscope.
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使用外部连接至内窥镜的桨式探头进行食管 OCT 成像。
DOI：
10.1007/s10620-021-07372-w
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发表时间：
2022
影响因子：
3.1
通讯作者：
Wax,Adam
中科院分区：
文献类型：
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作者：
Chu,KengyehK;Zhao,Yang;Jelly,EvanT;Steelman,ZacharyA;Crose,Michael;Cox,Brian;Ofori-Marfoh,Yaa;Moussa,Lama;Cirri,Holly;Watts,Ariel;Shaheen,Nicholas;Wax,Adam
背景和目的通过白光检查对巴雷特食管（BE）进行内窥镜监测不足以诊断发育不良性改变。在这项工作中，我们描述了一种光学成像方法，使用固定在内窥镜尖端的桨形探头来获得高分辨率横截面成像。方法我们将光学相干断层扫描（OCT）（一种产生横截面图像的光学成像方法）集成到连接到视频内窥镜的桨式探头中。我们从接受常规上消化道内窥镜检查的患者那里获取了食管上皮的图像。由不了解患者身份和病情的评审员对图像进行分类，并将这些结果与临床诊断进行比较。结果我们成功捕获了 30 名患者的上皮 OCT 图像，并确定了与鳞状上皮和巴雷特食管一致的特征。我们的盲法图像审阅者以 91.5% 的准确度（65/71 图像区域）对 BE 与非 BE 进行分类，其中 BE 的敏感性为 84.6% (11/13)，特异性为 93.1% (54/58)。然而，在 16 名患者中，无法实现将探头插管到食管中。结论 桨式探头是获取食管横截面 OCT 图像的可行成像格式，并且可以提供 BE 和非 BE 组织的结构评估。探头形状因素是当前的限制障碍，但可以通过进一步小型化来解决。
Background and AimsEndoscopic surveillance of Barrett’s esophagus (BE) by white light examination is insufficient to diagnose dysplastic change. In this work, we describe an optical imaging method to obtain high-resolution cross-sectional imaging using a paddle-shaped probe affixed to the endoscope tip.MethodsWe integrated Optical Coherence Tomography (OCT), an optical imaging method that produces cross-sectional images, into a paddle probe attached to video endoscope. We acquired images of esophageal epithelium from patients undergoing routine upper GI endoscopy. Images were classified by a reviewer blinded to patient identity and condition, and these results were compared with clinical diagnosis.ResultsWe successfully captured epithelial OCT images from 30 patients and identified features consistent with both squamous epithelium and Barrett’s esophagus. Our blinded image reviewer classified BE versus non-BE with 91.5% accuracy (65/71 image regions), including sensitivity of 84.6% for BE (11/13) and a specificity of 93.1% (54/58). However, in 16 patients, intubation of the probe into the esophagus could not be achieved.ConclusionsA paddle probe is a feasible imaging format for acquiring cross-sectional OCT images from the esophagus and can provide a structural assessment of BE and non-BE tissue. Probe form factor is the current limiting obstacle, but could be addressed by further miniaturization.