The influence of small bowel motion on both a conventional three-field and intensity modulated radiation therapy (IMRT) for rectal cancer.
The influence of small bowel motion on both a conventional three-field and intensity modulated radiation therapy (IMRT) for rectal cancer.
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DOI：
10.1016/j.canrad.2004.08.001
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发表时间：
2004-10-01
期刊：
影响因子：
--
通讯作者：
Martinez, Alvaro
中科院分区：
文献类型：
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作者：
Nuyttens, Joost J;Robertson, John M;Martinez, Alvaro
目的：探讨调强放射治疗(IMRT)计划对直肠癌患者照射后小肠体积的缩小作用，并通过每周CT扫描来评价常规计划下IMRT计划(IMPLAN)照射后小肠体积的变化。材料与材料：12例直肠癌患者在治疗计划中进行了盆腔CT扫描，并在治疗过程中获得小肠造影剂(共65次CT扫描)。扫描是使用骨骼结构进行注册的。临床靶区体积(CTV)、小肠、大肠和膀胱均在每张切片上勾勒出来。第一次CT扫描用于IMPLAN和常规三野计划(Conplan)，然后应用于治疗过程中获得的CT扫描。结果：在患者中，Conplan和IMPLAN的平均体积分别为112cm3(标准差：31cm3)和42cm3(SD：17cm3)。膀胱总容量中位数为148 cm~3(SD：130 cm~3)。照射后小肠体积与膀胱体积之间有较好的相关性。
PURPOSE: To investigate the reduction of irradiated small bowel volume with intensity modulated radiation therapy (IMRT) planning in rectal cancer and to asses the variability of the irradiated small bowel in the conventional planning as in the IMRT planning (IMPlan) by obtaining weekly CT scans.PATIENTS AND MATERIALS: Twelve patients with rectal cancer had treatment planning CT scans of the pelvis with small bowel contrast obtained for planning and once a week during treatment (65 CT scans total). The scans were registered using the bony structures. The clinical target volume (CTV), small bowel, large bowel and bladder were outlined on each slice. The first CT scan was used for IMPlan and conventional three-field planning (ConPlan), which were then applied to the CT scans obtained during therapy.RESULTS: The median value among patients of the mean volume over a patient's scan of small bowel irradiated > or =95% was 112 cm3 (standard deviation (SD): 31 cm3) for the ConPlan and 42 cm3 (SD: 17 cm3) for the IMPlan. The median total bladder volume was 148 cm3 (SD: 130 cm3). There was a good correlation between the volume of irradiated small bowel and the bladder volume for IMPlan with