Editorial overview: Not everyone can become a cell biologist, but a great cell biologist can come from anywhere
Editorial overview: Not everyone can become a cell biologist, but a great cell biologist can come from anywhere
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编辑概述：不是每个人都可以成为细胞生物学家，但伟大的细胞生物学家可以来自任何地方
DOI：
10.1016/j.pbi.2023.102367
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发表时间：
2023
影响因子：
9.5
通讯作者：
Mendoza-Cózatl, David G.
中科院分区：
文献类型：
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作者：
Mendoza-Cózatl, David G.
DNA折纸是一种基于DNA的纳米技术，利用短互补寡核苷酸的编程组合将大单链DNA折叠成精确的2D和3D形状。这种固有的生物相容性材料的精致纳米级形状控制与空间处理折纸结构的潜力相结合，包括药物、抗体、核酸序列、小分子和无机颗粒。这种可编程的灵活性使得精确的纳米级设备的制造已经在生物医学应用中显示出巨大的潜力，例如：药物输送，生物传感和合成纳米孔的形成。在这里，回顾了DNA -折纸领域自几年前成立以来的进展，重点是如何设计这些DNA -纳米器件与细胞相互作用以指导或探测它们的行为。
DNA origami is a DNA‐based nanotechnology that utilizes programmed combinations of short complementary oligonucleotides to fold a large single strand of DNA into precise 2D and 3D shapes. The exquisite nanoscale shape control of this inherently biocompatible material is combined with the potential to spatially address the origami structures with diverse cargoes including drugs, antibodies, nucleic acid sequences, small molecules, and inorganic particles. This programmable flexibility enables the fabrication of precise nanoscale devices that have already shown great potential for biomedical applications such as: drug delivery, biosensing, and synthetic nanopore formation. Here, the advances in the DNA‐origami field since its inception several years ago are reviewed with a focus on how these DNA‐nanodevices can be designed to interact with cells to direct or probe their behavior.