Histomorphometric analysis of age-related structural changes in human clitoral cavernosal tissue
Histomorphometric analysis of age-related structural changes in human clitoral cavernosal tissue
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DOI：
10.1016/s0022-5347(01)61825-1
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发表时间：
1999-03-01
影响因子：
6.6
通讯作者：
Azadzoi, KM
中科院分区：
文献类型：
--
作者：
Tarcan, T;Park, K;Azadzoi, KM
目的：描述人类阴蒂海绵体组织与年龄相关的组织学变化，并确定阴蒂海绵体组织与年龄相关的组织学变化是否与血管疾病相关的死亡率相关。材料和方法：从15具新鲜尸体（年龄：11至90岁）和3名接受阴蒂手术的患者（年龄：6个月至15岁）中获得人类阴蒂。阴蒂的横截面进行染色与Masson的三色和利用计算机辅助的组织形态图像分析，以确定阴蒂海绵体内容的平滑肌和结缔组织。结果：这些研究揭示了一个强有力的联系，在年龄的增加和减少阴蒂海绵体平滑肌纤维之间。在组织形态计量学上，阴蒂海绵体的百分比。6个月至15岁年龄组（n = 4）的平滑肌（平均值+/-标准误）为65 +/- 1.5，44至54岁年龄组（n = 7）为50 +/- 1.2，55至90岁年龄组（n = 7）为37 +/- 1.3（ANOVA，p = 0.0001）。在研究的18个组织中，阴蒂海绵体平滑肌百分比的降低与年龄的增加显著相关（简单回归，r = 0.61）。在44至90岁的年龄组中，阴蒂海绵体纤维化是显着更大的存在心血管疾病相关的死亡率相比，那些没有心血管疾病相关的mortality.Conclusion：这项研究表明，老龄化妇女进行阴蒂海绵体勃起组织的组织学变化。血管危险因素可能会对阴蒂海绵体组织的结构产生不利影响。这些发现可能是重要的病理生理学与年龄相关的女性性唤起障碍。
Purpose: To characterize age-associated histological changes of human clitoral cavernosal tissue and to determine whether age-related histological changes of clitoral cavernosal tissue correlate with vascular disease-related mortality.Materials and Methods: Human clitorises were Obtained from 15 fresh cadavers (age: 11 to 90 years) and from 3 patients undergoing clitoral surgery (age: 6 months to 15 years). Cross sections of the clitorises were stained with Masson's trichrome and utilized for computer assisted histomorphometric image analysis to determine the clitoral cavernosal content of smooth muscle and connective tissue.Results: These studies revealed a strong link, between increase in age and decreased clitoral cavernosal smooth muscle fibers. In histomorphometry, the percentage of clitoral cavernosal. smooth muscle (mean +/- standard error) in an age group of 6 months to 15 years (n = 4) was 65 +/- 1.5, in 44 to 54 years (n = 7) was 50 +/- 1.2, and in 55 to 90 years (n = 7) was 37 +/- 1.3 (ANOVA, p = 0.0001). In the 18 tissues studied, decrease in the percentage of clitoral cavernosal smooth muscle significantly correlated with increase in age (simple regression, r = 0.61). In the age group of 44 to 90 years, clitoral cavernosal fibrosis was significantly greater in the presence of cardiovascular disease-related mortality compared with those without cardiovascular disease-related mortality.Conclusion: This study shows that aging women undergo histological changes in clitoral cavernosal erectile tissue. Vascular risk factors may adversely affect the structure of clitoral cavernosal tissue. These findings may be of importance in the pathophysiology of age-associated female sexual arousal disorders.