Static and dynamic nanomechanical properties of human skin tissue using atomic force microscopy: Effect of scarring in the upper dermis
Static and dynamic nanomechanical properties of human skin tissue using atomic force microscopy: Effect of scarring in the upper dermis
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DOI：
10.1016/j.actbio.2012.06.042
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发表时间：
2012-11-01
影响因子：
9.7
通讯作者：
Tobin, D. J.
中科院分区：
文献类型：
--
作者：
Grant, C. A.;Twigg, P. C.;Tobin, D. J.
创伤性损伤后，皮肤有能力通过复杂的生化变化级联进行自我修复。真皮包含承重胶原网络结构，经过长时间重塑，影响其机械行为。本研究检测了来自人类皮肤的上层真皮的纳米力学和粘弹性特性，包括健康的完整组织和疤痕组织。广泛的纳米压痕分析表明，真皮疤痕组织表现出比健康的完整皮肤更僵硬的行为。疤痕皮肤也显示出较弱的粘弹性蠕变和能力，以耗散能量在生理相关的频率比相邻的完整的皮肤。这些结果进行了讨论，结合与正常真皮相比，瘢痕真皮中的胶原纤维的取向的视觉变化，如原子力显微镜成像所示。(C)2012 Acta Materialia Inc.由爱思唯尔有限公司出版。保留所有权利。
Following traumatic injury, skin has the capacity to repair itself through a complex cascade of biochemical change. The dermis, which contains a load-bearing collagenous network structure, is remodelled over a long period of time, affecting its mechanical behaviour. This study examines the nanomechanical and viscoelastic properties of the upper dermis from human skin that includes both healthy intact and scarred tissue. Extensive nanoindentation analysis shows that the dermal scar tissue exhibits stiffer behaviour than the healthy intact skin. The scar skin also shows weaker viscoelastic creep and capability to dissipate energy at physiologically relevant frequencies than the adjacent intact skin. These results are discussed in conjunction with a visual change in the orientation of collagenous fibrils in the scarred dermis compared with normal dermis, as shown by atomic force microscopy imaging. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.