Serum cartilage oligomeric matrix protein is correlated with quantitative magnetic resonance imaging and arthroscopic cartilage findings in anterior cruciate ligament deficient knees without osteoarthritic changes
Serum cartilage oligomeric matrix protein is correlated with quantitative magnetic resonance imaging and arthroscopic cartilage findings in anterior cruciate ligament deficient knees without osteoarthritic changes
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DOI：
10.1007/s10067-021-05800-w
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发表时间：
2021-06
影响因子：
3.4
通讯作者：
Yohei Nishida;Yusuke Hashimoto;K. Orita;Kazuya Nishino;Takuya Kinoshita;Hiroaki Nakamura
中科院分区：
文献类型：
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作者：
Yohei Nishida;Yusuke Hashimoto;K. Orita;Kazuya Nishino;Takuya Kinoshita;Hiroaki Nakamura
Introduction/ObjectivesTo investigate血清生物标志物[软骨寡聚基质蛋白（COMP）和基质金属蛋白酶-3（MMP-3）]水平和临床，磁共振成像（MRI），关节镜检查结果在前交叉韧带（ACL）缺陷膝关节X线片上没有骨关节炎的变化。术前测量血清COMP和MMP-3水平。通过计算斯皮尔曼相关系数，评估血清生物标志物水平与年龄、体重指数（BMI）、损伤持续时间、Tegner活动量表（TAS）评分、Lysholm膝关节评分、国际膝关节文献委员会评分、KT-1000关节测量仪测量值、全器官MRI评分（蠕虫）、MRI T2弛豫时间和关节镜国际腕关节研究学会（ICRS）分级的相关性。使用Mann-Whitney U检验确定术中发现（软骨、半月板）与血清生物标志物水平之间的相关性。进行多元回归分析，以探讨血清生物标志物水平和MRI和关节镜findings. Results 98例患者的平均年龄为23.7岁之间的相关性。较高的血清COMP水平与年龄较大和较高的BMI、TAS评分、血清MMP-3水平、蠕虫和T2弛豫时间（股骨内侧、胫骨内侧）相关。多因素分析显示血清COMP水平与蠕虫和ICRS分级独立相关。结论血清COMP水平与ACL缺陷膝关节的年龄、BMI、TAS评分和MMP-3水平相关，与蠕虫和ICRS分级独立相关。因此，血清COMP水平可以帮助检测软骨退变，即使在没有放射学骨关节炎改变的患者中也是如此。关键点·ACL缺陷膝关节中血清COMP与蠕虫和ICRS分级相关。·血清COMP水平可以帮助检测软骨退变，即使在没有放射学骨关节炎改变的患者中。
Introduction/objectivesTo investigate the association between serum biomarker [cartilage oligomeric matrix protein (COMP) and matrix metalloproteinase-3 (MMP-3)] levels and clinical, magnetic resonance imaging (MRI), and arthroscopic findings in anterior cruciate ligament (ACL)-deficient knees without osteoarthritic changes on radiographs.MethodPatients with ACL injury of Kellgren–Lawrence grade 0 or 1 were enrolled. Serum COMP and MMP-3 levels were measured preoperatively. Correlations of serum biomarker levels with age, body mass index (BMI), duration from time of injury, Tegner activity scale (TAS) score, Lysholm knee score, International Knee Documentation Committee score, KT-1000 arthrometer measurements, whole-organ MRI score (WORMS), MRI T2 relaxation time, and arthroscopic International Cartilage Research Society (ICRS) grade were assessed by calculating Spearman correlation coefficients. Associations between intraoperative findings (cartilage, meniscus) and serum biomarker levels were determined using the Mann–Whitney U test. Multiple regression analysis was performed to investigate the correlations between serum biomarker levels and MRI and arthroscopic findings.ResultsNinety-eight patients with a mean age of 23.7 years were enrolled. Higher serum COMP level was correlated with older age and higher BMI, TAS score, serum MMP-3 level, WORMS, and T2 relaxation times (medial femur, medial tibia). Multivariate analysis showed that the serum COMP level was independently associated with WORMS and ICRS grade.ConclusionsThe serum COMP level was correlated with age, BMI, TAS score, and MMP-3 level in ACL-deficient knees and was independently correlated with WORMS and ICRS grade. Thus, the serum COMP level can help detect cartilage degeneration even in patients without radiographic osteoarthritic changes.Key Points• Serum COMP correlated with WORMS and ICRS grade in ACL deficient knee.• The serum COMP level could help in detecting cartilage degeneration, even in patients with no radiographic osteoarthritic changes.