Envelope Stress Responses: An Interconnected Safety Net.
Envelope Stress Responses: An Interconnected Safety Net.
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DOI：
10.1016/j.tibs.2016.10.002
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发表时间：
2017-03
影响因子：
13.8
通讯作者：
Silhavy TJ
中科院分区：
文献类型：
--
作者：
Grabowicz M;Silhavy TJ
大肠杆菌细胞包膜是一个保护屏障，在前线与环境的相互作用。必须监测包膜生物发生的保真度，以建立和维持一个连续的屏障。事实上，信封也必须修复和修改，以应对环境的攻击。包膜应激反应（ESRs）感知包膜损伤或缺陷并改变转录组以减轻应激。我们将回顾最近对σE和Cpx系统的应力感应机制以及这些esr的相互作用的研究进展。小rna （sRNAs）是越来越突出的调控转录反应的压力。这些快速作用的调节因子也为细胞间esr调节提供了途径，当细胞面临多个同时的压力时，如感染期间，这可能是重要的。
The Escherichia coli cell envelope is a protective barrier at the frontline of interaction with the environment. Fidelity of envelope biogenesis must be monitored to establish and maintain a contiguous barrier. Indeed, the envelope must also be repaired and modified in response to environmental assaults. Envelope stress responses (ESRs) sense envelope damage or defects and alter the transcriptome to mitigate stress. We will review recent insights into stress sensing mechanisms of the σE and Cpx systems and the interaction of these ESRs. Small RNAs (sRNAs) are increasingly prominent regulators of the transcriptional response to stress. These fast-acting regulators also provide avenues for inter-ESR regulation that could be important when cells face multiple contemporaneous stresses, as is the case during infection.