Pleiotropic constraint hampers the resolution of sexual antagonism in vertebrate gene expression
Pleiotropic constraint hampers the resolution of sexual antagonism in vertebrate gene expression
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DOI：
10.1086/523954
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发表时间：
2008-01-01
影响因子：
2.9
通讯作者：
Ellegren, Hans
中科院分区：
文献类型：
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作者：
Mank, Judith E.;Hultin-Rosenberg, Lina;Ellegren, Hans
两性之间的许多生理和表型差异，以及男女生殖利益之间的差异，导致性冲突，这往往表现在基因组一级。性拮抗基因以牺牲另一种性别为代价使一种性别受益，并经历强大的压力来进化男性和女性特异性表达模式，以解决性冲突并最大限度地提高两性的适应性。性别偏见的基因表达最近已被证明为后生动物的转录组，这表明许多位点是性拮抗。然而，许多编码区在整个生物体的多个过程中发挥作用。这种多效性增加了任何给定基因选择的复杂性，这反过来可能会掩盖性别特异性选择压力，并阻碍性别偏见基因表达的进化。在这里，我们使用微阵列基因表达数据，结合数据的转录丰度从表达序列标签库，以证明基因座与性别偏见的基因表达显着多效性比无偏见的基因。这种关系是独立的性染色体基因剂量效应，结果是一致的两个研究生物，鸡和小鼠。这些结果表明，决议性拮抗基因的表达是由进化的限制作用于任何给定的拮抗位点。
The numerous physiological and phenotypic differences between the sexes, as well as the disparity between male and female reproductive interests, result in sexual conflicts, which are often manifested at the genomic level. Sexually antagonistic genes benefit one sex at the expense of the other and experience strong pressure to evolve male- and female-specific expression patterns to resolve sexual conflicts and maximize fitness for both sexes. Sex-biased gene expression has recently been demonstrated for much of the metazoan transcriptome, suggesting that many loci are sexually antagonistic. However, many coding regions function in multiple processes throughout the organism. This pleiotropy increases the complexity of selection for any given gene, which in turn may obscure sex-specific selective pressures and hamper the evolution of sex-biased gene expression. Here we use microarray gene expression data, in conjunction with data on transcript abundance from expressed sequence tag libraries, to demonstrate that loci with sex-biased gene expression are significantly less pleiotropic than unbiased genes. This relationship was independent of sex chromosome gene dosage effects, and the results were concordant across two study organisms, chicken and mouse. These results suggest that the resolution of sexually antagonistic gene expression is determined by the evolutionary constraints acting on any given antagonistic locus.