Survival strategies of Leishmania donovani in mammalian host macrophages
Survival strategies of Leishmania donovani in mammalian host macrophages
复制标题
DOI：
10.1016/s0923-2494(99)80040-6
复制
发表时间：
1998-09-01
期刊：
影响因子：
--
通讯作者：
Descoteaux, A
中科院分区：
文献类型：
--
作者：
Desjardins, M;Descoteaux, A
微生物已经进化出多种在宿主细胞内生存的策略。有些具有在吞噬溶酶体的恶劣环境中生存的分子机制；有些则具有在吞噬溶酶体的恶劣环境中生存的分子机制。另一些则逃离吞噬体，进入更舒适的细胞质环境；其他抑制吞噬体与富含水解酶的内吞细胞器的融合。原生动物寄生虫杜氏利什曼原虫的前鞭毛体形式就是这种情况，它存在于吞噬体中，对内体和溶酶体的融合特性较差。最近的结果表明，脂磷酸聚糖（LPG）是利什曼原虫的主要细胞表面分子，参与吞噬体成熟的抑制。我们实验室的进一步研究正在解决 LPG 调节吞噬体融合特性的分子作用机制及其对吞噬溶酶体生物发生的影响。
Microbes have evolved a variety of strategies to survive inside their host cells. Some have the molecular machinery to survive in the hostile environment of phagolysosomes; others escape the phagosome to the more cozy environment of the cell cytoplasm; others inhibit the phagosome fusion with hydrolase-enriched endocytic organelles. This is the case for the promastigote form of the protozoan parasite Leishmania donovani which resides in a phagosome displaying poor fusogenic properties towards endosomes and lysosomes. Recent results indicate that the lipophosphoglycan (LPG), the major cell surface molecule of Leishmania, is involved in the inhibition of phagosome maturation. Further studies in our laboratories are addressing the molecular mechanisms of action of LPG to modulate phagosome fusion properties and its effect on the biogenesis of phagolysosomes.