Chronic arthritis of rabbits induced by mycoplasmas. III. Induction with nonviable Mycoplasma arthritidis antigens.
Chronic arthritis of rabbits induced by mycoplasmas. III. Induction with nonviable Mycoplasma arthritidis antigens.
复制标题
支原体引起的家兔慢性关节炎。
DOI：
10.1002/art.1780250805
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发表时间：
1982
影响因子：
--
通讯作者：
Ward,JR
中科院分区：
文献类型：
--
作者：
Washburn,LR;Cole,BC;Ward,JR
预先暴露于关节炎支原体的家兔，在用非活性的关节炎支原体抗原激发的膝关节中，可使其随后发生慢性炎症。超免疫致敏的兔比感染致敏的兔发生更严重的关节炎。未致敏家兔对关节内注射无活力微生物的反应最低。这些结果表明，对持续存在的支原体抗原的免疫应答可能能够维持由活菌性关节炎诱导的关节炎兔的慢性炎症。
Preexposure of rabbits toMycoplasma arthritidispredisposed them to subsequent development of chronic inflammation in knee joints challenged with nonviableM arthritidisantigens. Rabbits sensitized by hyperimmunization developed a more severe arthritis than those sensitized by infection. Unsensitized rabbits responded minimally to intraarticular injection of nonviable organisms. These results suggested that an immune response to a persisting mycoplasmal antigen might be capable of sustaining chronic inflammation in rabbits with arthritis induced by viableM arthritidis.