A follow-up study of DSM-III-R generalized anxiety disorder with syndromal and subsyndromal major depression
A follow-up study of DSM-III-R generalized anxiety disorder with syndromal and subsyndromal major depression
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DOI：
10.1016/s0165-0327(00)00168-3
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发表时间：
2003-02-01
影响因子：
6.6
通讯作者：
Townsend, MH
中科院分区：
文献类型：
--
作者：
Barbee, JG;Billings, CK;Townsend, MH
目的：作者使用分类和维度分析研究了伴有抑郁症状的广泛性焦虑症的长期结局。方法：39例DSM-III-R诊断为广泛性焦虑障碍（GAD）伴抑郁症状的门诊患者（23例和16例）参加了为期11周的临床试验。初步筛选后约18个月，这些人再次进行了评估，使用结构化的诊断访谈和一组评定量表。结果：三个不同的组在随访时是可辨别的。23例（60%）患者仍为GAD综合征; 10例（43%）患者GAD部分缓解; 6例（15%）无症状。在基线时为MD综合征的23例患者中，13例（56%）在随访时仍为MD综合征。所有在随访时为MD综合征的患者也仍然为GAD综合征。结论：这项研究的结果是相当不同的，虽然他们支持的概念，广泛性焦虑症作为一种慢性疾病，在大多数患者，有或没有MD。基线时是否存在MD与亚综合征抑郁对结局的影响相对较小。随着时间的推移，亚综合征焦虑和抑郁症状的患者可能处于综合征障碍的特殊风险中。(C)2000 Elsevier Science B. V.保留所有权利。
Objective: The authors examined the long-term outcome of generalized anxiety disorder with depressive symptoms utilizing both categorical and dimensional analyses. Method: Thirty-nine out-patients with a DSM-III-R diagnosis of generalized anxiety disorder (GAD) with depressive symptoms, both with (n = 23) and without (n = 16) syndromal major depression (MD) participated in an 11-week clinical trial. Approximately 18 months after initial screening, these individuals were once again evaluated using a structured diagnostic interview and a battery of rating scales. Results: Three distinct groups were discernible at follow-up. Twenty-three (60%) of the patients remained syndromal for GAD; 10 patients (43%) were in partial remission from GAD; six (15%) were asymptornatic. Of the 23 patients who were syndromal for MD at baseline, 13 (56%) remained syndromal for MD at follow-up. All of the patients who were syndromal for MD at follow-up remained syndromal for GAD as well. Conclusions: Outcomes in this study were quite divergent, though they support the concept of GAD as a chronic illness in most patients, with or without MD. The presence or absence of MD versus subsyndromal depression at baseline appeared to have relatively little impact upon the outcome. Patients with subsyndromal anxiety and depressive symptoms may be at special risk for syndromal disorders over time. (C) 2000 Elsevier Science B.V. All rights reserved.