Keloids: Animal models and pathologic equivalents to study tissue fibrosis.
Keloids: Animal models and pathologic equivalents to study tissue fibrosis.
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DOI：
10.1016/j.matbio.2016.01.014
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Uitto J
中科院分区：
文献类型：
--
作者：
Marttala J;Andrews JP;Rosenbloom J;Uitto J
动物模型对纤维化的研究至关重要。瘢痕疙瘩是一种仅见于人类的独特类型的纤维性瘢痕，因此对研究这种疾病的发病机制及其治疗方案的人来说是一个挑战。在这里，描述了目前正在使用的几种纤维化动物模型，强调了最近的进展，并强调了令人鼓舞的挑战。
Animal models are crucial for the study of fibrosis. Keloids represent a unique type of fibrotic scarring that occurs only in humans, thus presenting a challenge for those studying the pathogenesis of this disease and its therapeutic options. Here, several animal models of fibrosis currently in use are described, emphasizing recent progress and highlighting encouraging challenges.