An educational video to increase clinical trials enrollment among breast cancer patients
An educational video to increase clinical trials enrollment among breast cancer patients
复制标题
DOI：
10.1007/s10549-009-0311-7
复制
发表时间：
2009-09-01
影响因子：
3.8
通讯作者：
Simon, Michael S.
中科院分区：
文献类型：
--
作者：
Du, Wei;Mood, Darlene;Simon, Michael S.
全国范围内只有 3% 的乳腺癌女性参加癌症临床试验。对临床试验缺乏认识是参与临床试验的重大障碍。在一家大型城市综合癌症中心进行了一项研究，目的是测试 (1) 18 分钟的教育视频对于改善在 Karmanos 癌症研究所就诊的新乳腺癌患者对临床试验和试验招募的态度的有效性，以及 (2) 评估对临床试验态度的种族差异。参与者被随机分配接受第一次肿瘤诊所预约之前的教育干预或标准护理。参与者完成了基线调查和干预后两周调查，以评估对参与临床试验的态度。在招募的 218 名受试者中，196 名（55% 白人 vs. 45% 非裔美国人 (AA)）符合条件的患者被纳入分析。在干预组中观察到治疗性临床试验注册人数略有增加，但没有统计学意义（10.4% vs. 6.1%；P = 0.277）。该干预措施也没有导致患者对测试后临床试验的态度明显改善。然而，在调整阶段后，AA 女性的入学率较低（OR = 0.282，P = 0.049）。 AA 女性的 5 个基线态度量表中，有 3 个的负分明显更高。该教育视频并没有显着增加乳腺癌临床试验的参与人数。 AA 女性对临床试验的消极态度显着高于白人女性，这一发现可能部分解释了入学方面的种族差异。教育视频仍然是一种简单且经济高效的患者教育方式。未来的研究应侧重于设计一个新的教育视频，专门针对 AA 人群中的文化和态度障碍，以更有效地改变态度并增加试验入学率。
Only 3% of women with breast cancer participate in cancer clinical trials nationwide. The lack of awareness about clinical trials is a significant barrier towards clinical trials participation. A study was conducted at a large urban Comprehensive Cancer Center to test (1) the effectiveness of an 18-min educational video on improving attitudes toward clinical trials and trials enrollment among new breast cancer patients seen at the Karmanos Cancer Institute, and (2) to assess racial differences in attitudes regarding clinical trials. Participants were randomized to either the educational intervention prior to their first oncology clinic appointment or to standard care. A baseline and 2-week post-intervention survey to assess attitudes toward clinical trials participation was completed by participants. Of 218 subjects recruited, 196 (55% white vs. 45% African American (AA)) eligible patients were included in the analysis. A small increase in therapeutic clinical trial enrollment was observed in the intervention arm but was not statistically significant (10.4% vs. 6.1%; P = 0.277). The intervention also did not result in a clear improvement in patients' attitudes toward clinical trials at posttest. However, a lower enrollment rate for the AA women was noted after adjusting for stage (OR = 0.282, P = 0.049). Significantly more negative scores were noted in 3 out of the 5 baseline attitudinal scales for AA women. The educational video did not significantly increase enrollment in breast cancer clinical trials. The findings that AA women had significantly more negative attitudes toward clinical trials than white women may partially explain the racial disparity in enrollment. An educational video remains a simple and cost-effective way to educate patients. Future studies should focus on designing a new educational video to specifically target cultural and attitudinal barriers in the AA population to more effectively change attitudes and increase trial enrollment.