Effects of the interaction of dietary fat and protein on N-nitrosobis(2-oxopropyl)amine-induced carcinogenesis and spontaneous lesions in Syrian golden hamsters.
Effects of the interaction of dietary fat and protein on N-nitrosobis(2-oxopropyl)amine-induced carcinogenesis and spontaneous lesions in Syrian golden hamsters.
复制标题
膳食脂肪和蛋白质相互作用对 N-亚硝基双（2-氧代丙基）胺诱导的叙利亚金仓鼠致癌和自发病变的影响。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
P. Pour
中科院分区：
文献类型：
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作者：
D. Birt;P. Pour
在旨在评估膳食脂肪和蛋白质相互作用对 N-亚硝基双（2-氧代丙基）胺 [(BOP) CAS: 60599-38-4] 诱导的致癌作用的影响的实验中，给叙利亚金仓鼠喂食了四种饮食。饮食由两种水平的膳食脂肪组成[4.5克（低脂肪，LF）或18克（高脂肪，HF）玉米油/385千卡（kcal）]。这些水平分别喂食两种水平的膳食蛋白质[9 g 低蛋白 (LP) 和 36 g 高蛋白 (HP) 酪蛋白/385 kcal]。这四种饮食在生命周期的两个不同时期喂给两组不同的仓鼠。为了测试饮食对肿瘤发生的影响，一组在 3 至 7 周龄时接受饮食。第 8 周时，皮下注射 10 mg BOP/kg 体重，并进行对照饮食 [9 g 玉米油（中等脂肪）和 18 g 酪蛋白（中等蛋白质）/385 kcal]。另一组在 8 周龄之前接受对照饮食，随后注射 BOP 并接受四种饮食。该小组旨在测试饮食对肿瘤发展的影响。描述了 BOP 引起的肺、肝、胆总管、胆囊和肾损伤；胰腺的结果单独报告。在 BOP 治疗后喂养四种饮食的仓鼠中，LF-LP 组的肿瘤最少，LF-HP 喂养和 HF-LP 喂养组的肿瘤产量中等，而给予 HF-HP 饮食的仓鼠肿瘤数量最多。几种特定的肿瘤类型显示出类似的模式。例如，在未接受 BOP 治疗的仓鼠中，肺腺瘤发生率较低，但 HF-HP 组的肺腺瘤发生率高于 BOP 后饲喂 LF-HP 饮食的仓鼠，但不受 LP 水平脂肪的影响。此外，在未接受 BOP 治疗的仓鼠和在 BOP 治疗之前或之后饲喂 LF-LP 水平的仓鼠中，观察到肾腺瘤的发生率较低（0.5% 发生率），但在所有其他 BOP 治疗组中，肾腺瘤的发生率为 8%。无论是否接受 BOP 治疗，接受 HF 饮食的雄性仓鼠中胆管囊性腺瘤的发病率最高，而仅在给予 HF-LP 饮食的雌性仓鼠中，BOP 治疗导致该病变的发生率增加。（摘要截断为 400 字）
Syrian golden hamsters were fed four diets in experiments designed to evaluate the effects of the interaction of dietary fat and protein on carcinogenesis induced by N-nitrosobis(2-oxopropyl)amine [(BOP) CAS: 60599-38-4]. The diets consisted of two levels of dietary fat [4.5 g (low fat, LF) or 18 g (high fat, HF) of corn oil/385 kilocalories (kcal)]. These levels were fed with each of two levels of dietary protein [9 g low-protein (LP) and 36 g high-protein (HP) casein/385 kcal]. The four diets were fed to two separate groups of hamsters at two different periods in their life-span. For testing of the effects of diet on tumor initiation, one group received the diets from 3 to 7 weeks of age. At 8 weeks, they were given injections sc of 10 mg BOP/kg body weight and placed on a control diet [9 g corn oil (medium fat) and 18 g casein (medium protein)/385 kcal]. The other group received control diet until 8 weeks of age, at which time they were given injections of BOP and placed on the four diets. This group was designed to test the effects of the diets on tumor development. BOP-induced lesions in the lungs, liver, common bile duct, gallbladder, and kidneys are described; results in the pancreas were reported separately. In hamsters fed the four diets after BOP treatment, the LF-LP groups had the fewest tumors, the LF-HP-fed and HF-LP-fed groups had intermediate yields of tumors, and the hamsters given HF-HP diet exhibited the largest numbers of neoplasms. Several specific tumor types showed a similar pattern. For example, the pulmonary adenoma incidence, which was low in the non-BOP-treated hamsters, was higher in the HF-HP group than in those fed LF-HP diet after BOP, but it was not influenced by fat at the LP level. In addition, renal adenomas were observed at a low incidence in non-BOP-treated hamsters and in hamsters fed LF-LP levels before or after BOP treatment (0.5% incidence) but were present at an 8% incidence in all other BOP-treated groups. The incidence of biliary cystic adenomas was highest in male hamsters that received HF diets, irrespective of BOP treatment, and BOP treatment resulted in increased yields of this lesion in females only in groups given HF-LP diet.(ABSTRACT TRUNCATED AT 400 WORDS)