A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection
A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection
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一种用于肿瘤成像和药物性肝损伤检测的新型近红外荧光发光探针
DOI：
10.1039/c8cc10286d
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发表时间：
2019
影响因子：
4.9
通讯作者：
Xiao Yuling
中科院分区：
文献类型：
--
作者：
Zeng Xiaodong;Chen Ziyang;Tang Lin;Yang Han;Liu Nan;Zhou Hui;Li Yang;Wu Junzhu;Deng Zixin;Yu Yi;Deng Hai;Hong Xuechuan;Xiao Yuling
合理设计和开发了一种新型近红外荧光发光探针，其具有肿瘤归巢五肽 CREKA（Cys-Arg-Glu-Lys-Ala），可特异性结合纤维蛋白-纤连蛋白复合物，用于生物医学成像。其在肿瘤成像和药物性肝损伤检测方面的优越实际应用首次得到充分证明。
A novel near-infrared fluorescent light-up probe with a tumor-homing pentapeptide, CREKA (Cys-Arg-Glu-Lys-Ala), specifically binds to fibrin–fibronectin complexes was rationally designed and developed for biomedical imaging. Its superior practical applications in tumor imaging and drug-induced liver injury detection are well demonstrated for the first time.