Maturation of medial temporal lobe response and connectivity during memory encoding
Maturation of medial temporal lobe response and connectivity during memory encoding
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DOI：
10.1016/j.cogbrainres.2005.07.007
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发表时间：
2005-09-01
期刊：
影响因子：
--
通讯作者：
Reiss, AL
中科院分区：
文献类型：
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作者：
Menon, V;Boyett-Anderson, JM;Reiss, AL
内侧颞叶（MTL）在记忆编码中起着重要作用。然而，MTL和其他参与记忆编码的大脑区域的发育和成熟却知之甚少。我们使用功能性磁共振成像来研究儿童和青少年在户外视觉场景编码过程中MTL的激活和有效连接。在这里，我们发现，MTL反应随年龄的增长而减少，而其与左背外侧前额叶皮层（PFC）的连接随着年龄的增长。我们的研究结果提供了证据，涉及MTL的本地和分布式记忆编码过程的可分离的成熟，并进一步表明，MTL和PFC之间的功能相互作用的增加可能是更有效的记忆编码策略的发展的基础。(c)2005 Elsevier B.V保留所有权利。
The medial temporal lobe (MTL) plays an important role in memory encoding. The development and maturation of MTL and other brain regions involved in memory encoding are, however, poorly understood. We used functional magnetic resonance imaging to examine activation and effective connectivity of the MTL in children and adolescents during encoding of outdoor visual scenes. Here, we show that MTL response decreases with age whereas its connectivity with the left dorsolateral prefrontal cortex (PFC) increases with age. Our findings provide evidence for dissociable maturation of local and distributed memory encoding processes involving the MTL and furthermore suggest that increased functional interactions between the MTL and the PFC may underlie the development of more effective memory encoding strategies. (c) 2005 Elsevier B.V All rights reserved.