Average lens density quantification with swept-source optical coherence tomography: optimized, automated cataract grading technique
Average lens density quantification with swept-source optical coherence tomography: optimized, automated cataract grading technique
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DOI：
10.1016/j.jcrs.2019.07.033
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发表时间：
2019-12-01
影响因子：
2.8
通讯作者：
Gatinel, Damien
中科院分区：
文献类型：
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作者：
Panthier, Christophe;de Wazieres, Alice;Gatinel, Damien
目的：评估基于扫频光学相干断层扫描 (SS-OCT) 扫描晶状体密度测量的客观白内障分级方法的修订版。地点：法国巴黎罗斯柴尔德基金会。设计：前瞻性病例系列。方法：纳入所有寻求白内障评估并同意参与研究的患者。排除标准是有眼科手术史、角膜或视网膜疾病以及眼部干燥。使用 MATLAB 软件开发的算法在 SS-OCT 扫描 (IOLMaster 700) 上测量平均晶状体密度 (ALD)。使用双通像差计（光学质量分析系统）测量眼散射指数（OSI）； Pentacam 核分期（PNS）评分；还测量了平均 PNS 并与 ALD 测量值进行比较。 结果：纳入了 155 名年龄 20 至 93 岁（平均 56.5 岁 21 [SD]）患者的 285 只眼睛（195 只患有白内障；90 只对照眼）。 ALD 测量是可重复的（P = .99，方差分析）。重复性限制为 2.50 像素单位。 ALD 与 OSI (r(2) = 0.41，P < .01) 和 PNS 评分 (r(2) = 0.65，P
Purpose: To assess a revised version of an objective cataract grading method based on the lens densitometry on swept source optical coherence tomography (SS-OCT) scans.Setting: Rothschild Foundation, Paris, France.Design: Prospective case series.Methods: All patients seeking a cataract evaluation and consenting to study participation were included. Exclusion criteria were a history of ocular surgery, cornea or retina disorders, and ocular dryness. The average lens densitometry (ALD) was measured on SS-OCT scans (IOLMaster 700) using an algorithm developed with MATLAB software. The ocular scatter index (OSI), measured using a double-pass aberrometer (Optical Quality Analysis System); Pentacam nucleus staging (PNS) score; and mean PNS were also measured and compared with the ALD measurements.Results: Two hundred eighty-five eyes (195 with cataract; 90 controls) of 155 patients aged 20 to 93 years (mean 56.5 years 21 [SD]) were included. The ALD measurements were repeatable (P = .99, analysis of variance). The repeatability limit was 2.50 pixel units. The ALD correlated with the OSI (r(2) = 0.41, P < .01) and PNS score (r(2) = 0.65, P