Integration of Light and Photoperiodic Signaling in Transcriptional Nuclear Foci.
Integration of Light and Photoperiodic Signaling in Transcriptional Nuclear Foci.
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DOI：
10.1016/j.devcel.2015.10.008
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发表时间：
2015-11-09
影响因子：
11.8
通讯作者：
Chory J
中科院分区：
文献类型：
--
作者：
Kaiserli E;Páldi K;O'Donnell L;Batalov O;Pedmale UV;Nusinow DA;Kay SA;Chory J
光通过安排一系列的核事件来调节主要的植物发育转变。本研究揭示了天然变异体TZP(Tandem Zinc-Finger-Plus3)作为一种新的光和光周期信号整合因子在转录核焦点中的分子功能。我们报道，TZP通过与红光受体光敏色素B(PhyB)的物理相互作用，对光周期开花起到积极的调节作用。我们证明了TZP定位于受光质和光周期调控的动态核域。这项研究表明，PhyB不仅是将TZP定位到转录活性的核光体上所必需的，也是在花诱导开花基因T(FT)的启动子上募集TZP所必需的。我们的发现表明，TZP对高度神秘的植物核光体具有独特的转录调控作用，TZP直接激活FT基因的表达，促进开花。
Light regulates major plant developmental transitions by orchestrating a series of nuclear events. This study uncovers the molecular function of the natural variant, TZP (Tandem Zinc-finger-Plus3), as a novel signal integrator of light and photoperiodic pathways in transcriptional nuclear foci. We report that TZP acts as a positive regulator of photoperiodic flowering via physical interactions with the red-light receptor phytochrome B (phyB). We demonstrate that TZP localizes in dynamic nuclear domains regulated by light quality and photoperiod. This study shows that phyB is indispensible not only for localizing TZP to transcriptionally active nuclear photobodies, but also for recruiting TZP on the promoter of the floral inducer FLOWERING LOCUS T (FT). Our findings signify a unique transcriptional regulatory role to the highly enigmatic plant nuclear photobodies, where TZP directly activates FT gene expression and promotes flowering.