Highly directional transurethral ultrasound applicators with rotational control for MRI-guided prostatic thermal therapy.
Highly directional transurethral ultrasound applicators with rotational control for MRI-guided prostatic thermal therapy.
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具有旋转控制功能的高度定向经尿道超声探头，用于 MRI 引导的前列腺热疗。
DOI：
10.1088/0031-9155/49/2/002
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发表时间：
2004
影响因子：
3.5
通讯作者：
Sommer,Graham
中科院分区：
文献类型：
--
作者：
Ross,AnthonyB;Diederich,ChrisJ;Nau,WilliamH;Gill,Harcharan;Bouley,DonnaM;Daniel,Bruce;Rieke,Viola;Butts,RKim;Sommer,Graham
Transurethral ultrasound applicators with highly directional energy deposition and rotational control were investigated for precise treatment of benign prostatic hyperplasia (BPH) and adenocarcinoma of the prostate (CaP). Two types of catheter-based applicators were fabricated, using either 90 sectored tubular (3.5 mm OD× 10 mm) or planar transducers (3.5 mm× 10 mm). They were constructed to be MRI compatible, minimally invasive and allow for manual rotation of the transducer array within a 10 mm cooling balloon. In vivo evaluations of the applicators were performed in canine prostates (n= 3) using MRI guidance (0.5 T interventional magnet). MR temperature imaging (MRTI) utilizing the proton resonance frequency shift method was used to acquire multiple-slice temperature overlays in real time for monitoring and guiding the thermal treatments. Post-treatment T1-weighted contrast-enhanced imaging and triphenyl tetrazolium chloride stained tissue sections were used to define regions of tissue coagulation. Single sonications with the 90 tubular applicator (9–15 W, 12 min, 8 MHz) produced coagulated zones covering an 80 wedge of the prostate extending from 1–2 mm outside the urethra to the outer boundary of the gland (16 mm radial coagulation). Single sonications with the planar applicator (15–20 W, 10 min,∼ 8 MHz) generated thermal lesions of∼ 30 extending to the prostate boundary. Multiple sequential sonications (sweeping) of a planar applicator (12 W with eight rotations of 30 each) demonstrated controllable coagulation of a 270 contiguous section of the prostate extending to the capsule boundary. The feasibility of using highly directional transurethral ultrasound applicators with rotational capabilities to selectively coagulate regions of the prostate while monitoring and controlling the treatments with MRTI was demonstrated in this study.
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DOI：
10.1016/s0022-5347(05)65658-3
发表时间：
2001
期刊：
The Journal of urology
影响因子：
--
作者：
M. Sherar;M. Gertner;Clarence K. K. Yue;Martin E. O’Malley;Ants Toi;A. Gladman;S. Davidson;J. Trachtenberg
通讯作者：
J. Trachtenberg
影响因子：
3.3
作者：
H. Stewart
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H. Stewart
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影响因子：
2.1
作者：
T. Larson
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影响因子：
3.2
作者：
C. Lafon;F. Chavrier;F. Prat;J. Chapelon;D. Cathignol
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D. Cathignol
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影响因子：
2.9
作者：
Cyril Lafon;Y. Theillère;Frédéric Prat;A. Arefiev;J. Chapelon;Dominique Cathignol
通讯作者：
Dominique Cathignol