Memory enhancement and deep-brain stimulation of the entorhinal area.
Memory enhancement and deep-brain stimulation of the entorhinal area.
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DOI：
10.1056/nejmoa1107212
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发表时间：
2012-02-09
期刊：
影响因子：
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通讯作者：
Fried I
中科院分区：
文献类型：
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作者：
Suthana N;Haneef Z;Stern J;Mukamel R;Behnke E;Knowlton B;Fried I
内侧颞叶结构，包括海马体和内嗅皮层，对于将日常经历转化为持久记忆的能力至关重要。我们测试了海马或内嗅皮层的深部脑刺激会改变记忆表现的假设。我们在七名受试者身上植入了颅内深度电极，以确定癫痫发作区域，以便进行后续的癫痫手术。受试者完成了一项空间学习任务，在此期间他们学习了虚拟环境中的目的地。在一半的学习试验中，局部电刺激低于引发后放电（即刺激终止后发生的神经元放电）的阈值。在受试者学习地标位置时施加内嗅刺激增强了他们对这些位置的后续记忆：与没有刺激的情况下学习的位置相比，受试者更快、更短的路线到达这些地标。内嗅刺激还导致 θ 节律相位重置，如海马脑电图所示。直接海马刺激无效。在这个小系列中，没有观察到与手术相关的不良事件。在学习过程中刺激内嗅区域可以增强空间信息的记忆。 （由美国国立卫生研究院和达纳基金会资助。）
The medial temporal structures, including the hippocampus and the entorhinal cortex, are critical for the ability to transform daily experience into lasting memories. We tested the hypothesis that deep-brain stimulation of the hippocampus or entorhinal cortex alters memory performance. We implanted intracranial depth electrodes in seven subjects to identify seizure-onset zones for subsequent epilepsy surgery. The subjects completed a spatial learning task during which they learned destinations within virtual environments. During half the learning trials, focal electrical stimulation was given below the threshold that elicits an afterdischarge (i.e., a neuronal discharge that occurs after termination of the stimulus). Entorhinal stimulation applied while the subjects learned locations of landmarks enhanced their subsequent memory of these locations: the subjects reached these landmarks more quickly and by shorter routes, as compared with locations learned without stimulation. Entorhinal stimulation also resulted in a resetting of the phase of the theta rhythm, as shown on the hippocampal electroencephalogram. Direct hippocampal stimulation was not effective. In this small series, no adverse events associated with the procedure were observed. Stimulation of the entorhinal region enhanced memory of spatial information when applied during learning. (Funded by the National Institutes of Health and the Dana Foundation.)