Risk factors for Marburg hemorrhagic fever, Democratic Republic of the Congo
Risk factors for Marburg hemorrhagic fever, Democratic Republic of the Congo
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DOI：
10.3201/eid0912.030355
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发表时间：
2003-12-01
影响因子：
11.8
通讯作者：
Rollin, PE
中科院分区：
文献类型：
--
作者：
Bausch, DG;Borchert, M;Rollin, PE
我们进行了两次抗体调查，以评估刚果民主共和国确认的马尔堡病毒传播地区发生马尔堡出血热的风险因素。施用血清样品，并通过酶联免疫吸附测定法检测马尔堡特异性抗体。在一般村横断面抗体调查的912名参与者中，有15名（2%）马尔堡免疫球蛋白G抗体阳性。这15人中有13人（87%）是在当地金矿工作的男子。作为矿工工作（比值比[OR] 13.9，95%置信区间[CI] 3.1至62.1）和接受注射（OR 7.4，95% CI 1.6至33.2）与阳性抗体结果相关。所有103名参与针对性抗体调查的医护人员均为抗体阴性。马尔堡病毒向人类的主要传播可能是通过暴露于当地矿山中尚未确定的水库发生的。马尔堡病毒的二次传播似乎比另一种已知的丝状病毒埃博拉病毒更不常见。
We conducted two antibody surveys to assess risk factors for Marburg hemorrhagic fever in an area of confirmed Marburg virus transmission in the Democratic Republic of the Congo. Questionnaires were administered and serum samples tested for Marburg-specific antibodies by enzyme-linked immunosorbent assay. Fifteen (2%) of 912 participants in a general village cross-sectional antibody survey were positive for Marburg immunoglobulin G antibody. Thirteen (87%) of these 15 were men who worked in the local gold mines. Working as a miner (odds ratio [OR] 13.9, 95% confidence interval [CI] 3.1 to 62.1) and receiving injections (OR 7.4, 95% CI 1.6 to 33.2) were associated with a positive antibody result. All 103 participants in a targeted antibody survey of healthcare workers were antibody negative. Primary transmission of Marburg virus to humans likely occurred via exposure to a still unidentified reservoir in the local mines. Secondary transmission appears to be less common with Marburg virus than with Ebola virus, the other known filovirus.