Local Innate Immune Responses and Influenza Virus Transmission and Virulence in Ferrets
Local Innate Immune Responses and Influenza Virus Transmission and Virulence in Ferrets
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DOI：
10.1093/infdis/jir768
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发表时间：
2012-02-01
影响因子：
6.4
通讯作者：
Tumpey, Terrence M.
中科院分区：
文献类型：
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作者：
Maines, Taronna R.;Belser, Jessica A.;Tumpey, Terrence M.
宿主的先天免疫是抵御包括流感病毒在内的病原体入侵的第一道防线。雪貂被公认为流感病毒致病和传播的最佳模型，但对雪貂感染该病毒后的先天免疫反应知之甚少。本研究的目的是调查本地化的主机响应流感病毒的致病性和传播性在这个模型中的贡献，通过测量的信使RNA表达水平的12种细胞因子和趋化因子在雪貂感染H5N1，H1N1，或H3N2流感病毒，表现出不同的毒力和雪貂的上，下呼吸道。我们发现炎症介质与传播的动力学和频率、与传播相关的临床体征、病毒脱落峰值和毒力之间存在很强的时间相关性。我们的发现指出了局部先天免疫与流感病毒传播和疾病进展之间的联系。
Host innate immunity is the first line of defense against invading pathogens, including influenza viruses. Ferrets are well recognized as the best model of influenza virus pathogenesis and transmission, but little is known about the innate immune response of ferrets after infection with this virus. The goal of this study was to investigate the contribution of localized host responses to influenza virus pathogenicity and transmissibility in this model by measuring the level of messenger RNA expression of 12 cytokines and chemokines in the upper and lower respiratory tracts of ferrets infected with H5N1, H1N1, or H3N2 influenza viruses that exhibit diverse virulence and transmissibility in ferrets. We found a strong temporal correlation between inflammatory mediators and the kinetics and frequency of transmission, clinical signs associated with transmission, peak virus shedding, and virulence. Our findings point to a link between localized innate immunity and influenza virus transmission and disease progression.