In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography.
In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography.
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DOI：
10.1364/boe.3.002700
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发表时间：
2012-11-01
影响因子：
3.4
通讯作者：
Park BH
中科院分区：
文献类型：
--
作者：
Eberle MM;Reynolds CL;Szu JI;Wang Y;Hansen AM;Hsu MS;Islam MS;Binder DK;Park BH
最常用的癫痫检测技术是脑电图（EEG），它具有低空间分辨率和最小深度识别。使用近红外（NIR）光的光学技术已被用于改进脑电图技术，先前的研究表明，在体内模型中，光学变化，特别是近红外光学散射的变化可能先于脑电图发作。光学相干断层扫描（OCT）是一种高分辨率、微创成像技术，可以产生深度分辨率的横截面图像。在这项研究中，OCT被用于检测小鼠体内皮质组织的光学特性的变化，在诱导全身性癫痫活动之前和期间。我们发现，在出现可观察到的全身性（第5期）癫痫发作症状之前，在癫痫发作过程中可以检测到背散射强度的显著降低（P < 0.001）。这些结果提示了OCT微创光学检测癫痫发作的可行性。
The most common technology for seizure detection is with electroencephalography (EEG), which has low spatial resolution and minimal depth discrimination. Optical techniques using near-infrared (NIR) light have been used to improve upon EEG technology and previous research has suggested that optical changes, specifically changes in near-infrared optical scattering, may precede EEG seizure onset in in vivo models. Optical coherence tomography (OCT) is a high resolution, minimally invasive imaging technique, which can produce depth resolved cross-sectional images. In this study, OCT was used to detect changes in optical properties of cortical tissue in vivo in mice before and during the induction of generalized seizure activity. We demonstrated that a significant decrease (P < 0.001) in backscattered intensity during seizure progression can be detected before the onset of observable manifestations of generalized (stage-5) seizures. These results indicate the feasibility of minimally-invasive optical detection of seizures with OCT.