The relationship between FDG uptake in PET scans and biological behavior in breast cancer.
The relationship between FDG uptake in PET scans and biological behavior in breast cancer.
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DOI：
10.2325/jbcs.14.260
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Sunagawa, Masakatsu
中科院分区：
文献类型：
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作者：
Shimoda, Wataru;Hayashi, Mitsuhiro;Sunagawa, Masakatsu
背景：正电子发射断层扫描（PET）是一种用于乳腺癌诊断和分期的非侵入性成像方式。然而，几个因素可以影响肿瘤对氟脱氧葡萄糖（FDG）的摄取。为了澄清的参数，最影响FDG在肿瘤中的积累，标准化摄取值（SUV）和临床病理因素和免疫组织病理学分析之间的关系进行了研究，在乳腺cancer.MATERIAL和方法：PET研究进行术前37例乳腺癌。在FDG注射后1小时（早期）和2小时（延迟期）计数SUV。研究SUVs与13项临床、病理及免疫组化指标的关系。发现FDG蓄积与早期和延迟期有丝分裂计数之间存在显著相关性（分别为p=0.0018和0.0010）、Ki 67阳性细胞百分比（分别为p=0.0098和0.0062）和核分级（分别为p=0.0232和0.0195）。另一方面，淋巴结状态与延迟相弱相关（p=0.0907）。然而，其他临床病理参数和免疫组织病理学状态，包括肿瘤大小、年龄、组织学、雌激素受体、孕激素受体和Her 2/neu过表达，与FDG摄取无明显相关性。结论：有丝分裂计数和Ki 67反映细胞的侵袭性。这些参数与示踪剂的吸收密切相关。因此，我们的数据表明，乳腺癌的生物学行为反映在肿瘤摄取FDG的变化。然而，FDG摄取是否是一个真正的预后和预测因素仍有待于在更大的研究在一个较长的时间内证实。
BACKGROUND: Positron emission tomography (PET) is a non-invasive imaging modality used in the diagnosis and staging of breast cancer. However, several factors can affect fluoro-deoxyglucose (FDG) uptake by a tumor. To clarify the parameters that most affect FDG accumulation in tumors, the relationship between standardized uptake values (SUVs) and clinicopathological factors and immunohistopathological analysis was investigated in breast cancer.MATERIAL AND METHODS: PET studies were performed preoperatively on 37 patients with breast carcinoma. SUVs were counted at one hour (early phase) and at two hours (delayed phase) after FDG injection. The relationships between SUVs and 13 clinical, pathological and immunohistchemical factors were studied.RESULTS: A significant association was found between FDG accumulation and early and delayed phase mitotic counts (p=0.0018 and 0.0010, respectively), Ki67 positive cell percentage (p=0.0098 and 0.0062, respectively), and nuclear grade (p=0.0232 and 0.0195, respectively). On the other hand, nodal status weakly correlated with the delayed phase (p=0.0907). However, other clinicopathological parameters and immunohistopathological status, which included tumor size, age, histology, estrogen receptor, progesterone receptor and Her2/neu overexpression, did not correlate significantly with FDG uptake.CONCLUSION: Mitotic count and Ki67 reflect cellular aggressiveness. These parameters were strongly correlated with tracer uptake. Thus our data suggested that the biological behavior of breast cancer is reflected in the variation of FDG uptake by the tumor. However, whether FDG uptake is a true prognostic and predictive factor remains to be confirmed in larger studies over an extended period of time.