Hyperhomocysteinemia in chronic alcoholism: Correlation with folate, vitamin B-12, and vitamin B-6 status
Hyperhomocysteinemia in chronic alcoholism: Correlation with folate, vitamin B-12, and vitamin B-6 status
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DOI：
10.1093/ajcn/63.2.220
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发表时间：
1996-02-01
影响因子：
7.1
通讯作者：
Mira, FC
中科院分区：
文献类型：
--
作者：
Cravo, ML;Gloria, LM;Mira, FC
血清同型半胱氨酸浓度已被证明是细胞内叶酸、维生素 B-12 和维生素 B-6 状态的敏感功能指标。众所周知，慢性酒精中毒会干扰一碳代谢，而上述维生素则充当辅酶。在本研究中，通过测量血液维生素浓度以及血清同型半胱氨酸浓度，对 32 名慢性酗酒者和 31 名健康志愿者的这些维生素进行了评估。慢性酗酒者的血清 5'-磷酸吡哆醛和红细胞叶酸浓度显着低于对照组（分别为 P < 0.001 和 P = 0.008）。慢性酗酒者的平均血清同型半胱氨酸是不饮酒者的两倍（P < 0.001）。与饮用葡萄酒或烈酒的人相比，啤酒消费者的同型半胱氨酸浓度显着降低（P = 0.05）。这些结果表明，通过干扰叶酸或维生素 B-6 代谢，长期饮酒可能会损害同型半胱氨酸通过转甲基或转硫途径的处理。
Serum homocysteine concentrations have been shown to be a sensitive functional indicator of intracellular folate, vitamin B-12, and vitamin B-6 status. Chronic alcoholism is known to interfere with one-carbon metabolism, for which the above vitamins serve as coenzymes. In the present study, these vitamins were assessed in 32 chronic alcoholics and 31 healthy volunteers by measuring blood vitamin concentrations as well as serum homocysteine concentrations. In chronic alcoholics, serum pyridoxal 5'-phosphate and red blood cell folate concentrations were significantly lower than in the control subjects (P < 0.001 and P = 0.008, respectively). Mean serum homocysteine was twice as high in chronic alcoholics than in nondrinkers (P < 0.001). Beer consumers had significantly lower concentrations of homocysteine compared with drinkers of wine or spirits (P = 0.05). These results suggest that by interfering with folate or vitamin B-6 metabolism, chronic alcohol intake may impair the disposal of homocysteine through the transmethylation or transsulfuration pathways.